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PSMD4 — SNRPA

Text-mined interactions from Literome

Eperon et al., Mol Cell Biol 2000 : Strikingly, SF2/ASF , one of the essential SR protein splicing factors, causes a dose dependent shift in splicing to a downstream ( intron-proximal ) site, and yet it increases U1 snRNP binding at upstream and downstream sites simultaneously ... Cross linking experiments show that SF2/ASF and hnRNP A1 compete to bind pre-mRNA, and we conclude that this competition is the basis of their functional antagonism ; SF2/ASF enhances U1 snRNP binding at all 5'SSs, the rise in simultaneous occupancy causing a shift in splicing towards the downstream site, whereas hnRNP A1 interferes with U1 snRNP binding such that 5'SS occupancy is lower and the affinities of U1 snRNP for the individual sites determine the site of splicing
Martins de Araújo et al., RNA 2009 (Muscular Atrophy, Spinal) : Two trans acting factors implicated in SMN regulation , SF2/ASF and hnRNP A1, promote and repress, respectively, U2 snRNP recruitment to both RNAs