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Yao et al., Nat Med 2010
(Cocaine-Related Disorders...) :
PKA and PKC phosphorylate and activate tyrosine hydroxylase , further increasing dopamine synthesis in a positive-feedback loop
Aguila-Mansilla et al., J Pharmacol Exp Ther 1993
:
Localization of a defect in hypothalamic dopaminergic neurons of the aged brain that results in impaired PKA dependent activation of tyrosine hydroxylase Kim et al., J Neurochem 1994
(Neuroblastoma) :
To define the precise role of cyclic AMP ( cAMP ) -dependent protein kinase (PKA) in transcriptional regulation of the tyrosine hydroxylase (TH) gene, we performed transient cotransfection analyses of a reporter construct containing the upstream 2,400 bp sequence of the rat TH gene with expression plasmids encoding a heat-stable specific inhibitor of PKA ( PKI ), a mutant regulatory subunit of PKA, or the catalytic subunit of PKA