Ishikawa et al., Tumour Biol 1999
(Carcinoma, Hepatocellular...) :
HB-EGF selectively suppressed the AFP enhancer activity, resulting in decreased levels of both albumin and AFP mRNA in HuH-7 cells
Osawa et al., Biochem Biophys Res Commun 2001
(Carcinoma, Hepatocellular) :
In DMS treated cells, 9-cis retinoic acid ( RA ) further enhanced HNF-4alpha and albumin expression but it inhibited AFP accumulation