Nagajothi et al., Leukemia & lymphoma 2004
(Hemoglobinuria, Paroxysmal) :
We compared the cytotoxic activity of rituximab against a PNH B cell line, LD -, and the isogenic cell line LD - PIGA + in which GPI-anchor expression was restored by stable transfection of PIGA Krawitz et al., Blood 2013
(Hemoglobinuria, Paroxysmal) :
PIGA is essential for GPI anchor synthesis, whereas PIGT is essential for attachment of the preassembled GPI anchor to proteins