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CASP9 — IRF1
Text-mined interactions from Literome
Sancéau et al., Oncogene 2000
(Sarcoma, Ewing) :
IFN-beta induces serine phosphorylation of Stat-1 in Ewing 's sarcoma cells and mediates apoptosis via induction of
IRF-1 and
activation of
caspase-7
Fantuzzi et al., Eur J Immunol 2001
:
In conclusion,
IRF-1 regulates IL-18 production and activity mostly by modulating expression of
caspase-1 and IL-18BP ... In conclusion,
IRF-1 regulates IL-18 production and activity mostly by modulating expression of
caspase-1 and IL-18BP
Fulda et al., Oncogene 2002
(Neoplasms) :
Moreover, ectopic expression of
IRF1 induced
caspase-8 expression thereby sensitizing cells for TRAIL-, APO1- or doxorubicin induced apoptosis
Detjen et al., Int J Oncol 2002
(Carcinoma, Neuroendocrine...) :
Taken together our results characterize IFN-gamma as a potent proapoptotic stimulus in a subset of gastrointestinal NETs and suggest an
IRF-1 mediated induction of
caspase-1 as a relevant underlying mechanism
Suk et al., J Pharmacol Exp Ther 2003
:
Moreover, baicalein inhibited LPS induced nuclear factor-kappaB (NF-kappaB) activity in BV-2 cells without affecting
caspase-11 activation,
interferon regulatory factor-1 induction , or signal transducer and activator of transcription-1 phosphorylation ... Moreover, baicalein inhibited LPS induced nuclear factor-kappaB (NF-kappaB) activity in BV-2 cells without affecting
caspase-11 activation,
interferon regulatory factor-1 induction , or signal transducer and activator of transcription-1 phosphorylation
Ruiz-Ruiz et al., J Biol Chem 2004
(Breast Neoplasms) :
The up-regulation of human
caspase-8 by interferon-gamma in breast tumor cells
requires the induction and action of the transcription factor
interferon regulatory factor-1
Bowie et al., Oncogene 2004
:
Treatment of acutely damaged HMEC-E6 cells with 1.0 microM Tam resulted in recruitment of CBP to the gamma-IFN activated sequence element of the IRF-1 promoter, induction of
IRF-1 , and sequential
activation of
caspase-1 and -3
De Ambrosis et al., Int J Cancer 2007
(Neuroblastoma) :
Moreover, RNA interference experiments also supported the
involvement of
IRF-1 and IRF-2 in constitutive
caspase-8 expression in NB cells
Stang et al., Oncogene 2007
(Breast Neoplasms) :
Here we demonstrate that in MDA468 breast cancer cells, apoptosis by IFN-gamma is mediated by
IRF-1 and IFN-gamma, and IRF-1 induced apoptosis is
caspase mediated ...
IRF-1 induction
results in cleavage of
caspase-8 , -3 and -7, and application of caspase inhibitors attenuate activated cleavage products
Liu et al., J Biol Chem 2012
(Disease Models, Animal...) :
Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of
interferon regulatory factor-1 dependent
caspase 8 activation ... Meanwhile, overexpression or knockdown of
IRF-1 not only enhanced or
inhibited GMC apoptosis and
caspase 8 and 3 induction but also increased or decreased caspase 8 promoter activity, respectively