Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of MYC-ZBTB17
→
SMAD3
(decreases, MYC/ZBTB17 Activity)
Seoane et al., Nat Cell Biol 2001 Evidence: Here we provide evidence that TGFbeta signalling prevents recruitment of Myc to the p15INK4b transcriptional initiator by Myc-interacting zinc-finger protein 1 (Miz-1). This relieves repression and enables transcriptional activation by a TGFbeta-induced Smad protein complex that recognizes an upstream p15INK4b promoter region and contacts Miz-1. (from Weinberg - Pathways in Human Cancer poster, SMAD = SMAD 2/3) (MIZ-1 = ZBTB17)
OpenBEL Selventa BEL large corpus:
ZBTB17
→
SMAD3
(increases, SMAD3 Activity, ZBTB17 Activity)
Seoane et al., Nat Cell Biol 2001 Evidence: Here we provide evidence that TGFbeta signalling prevents recruitment of Myc to the p15INK4b transcriptional initiator by Myc-interacting zinc-finger protein 1 (Miz-1). This relieves repression and enables transcriptional activation by a TGFbeta-induced Smad protein complex that recognizes an upstream p15INK4b promoter region and contacts Miz-1. (from Weinberg - Pathways in Human Cancer poster, SMAD = SMAD 2/3) (MIZ-1 = ZBTB17)