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IL13 — JAK2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Doucet et al., Eur J Immunol 2002
(Inflammation) :
Treatment with JAK3 inhibitors blocks
IL-13 induced phosphorylation of
JAK2 , TYK2 and STAT3, but not of JAK1 and STAT6
Roy et al., J Leukoc Biol 2002
(Inflammation) :
Earlier, our laboratory showed that
IL-13 induced the phosphorylation of
Jak2 and Tyk2 in monocytes and that expression of both Jaks was essential for downstream signaling by IL-13
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Nishimura et al., Circ J 2008
:
IL-13 activated signal transduction and transcription 6 ( STAT6 ) as a
result of the activation of
Janus kinase 2 (JAK2) ...
IL-13 has anti-angiogenic activity as a
result of activation of
JAK2 and subsequent activation of STAT6
Raia et al., Cancer Res 2011
(Hodgkin Disease...) :
In both lymphoma cell lines, we observe
interleukin-13 (IL13) induced
activation of IL4 receptor a,
JAK2 , and STAT5, but not of STAT6
Russell et al., Islets 2013
:
Differential
effects of
interleukin-13 and interleukin-6 on
Jak/STAT signaling and cell viability in pancreatic ß-cells
Murata et al., J Immunol 1996
(Colonic Neoplasms) :
IL-13 induces phosphorylation and activation of JAK2
Janus kinase in human colon carcinoma cell lines : similarities between IL-4 and IL-13 signaling
Murata et al., Blood 1998
:
Taken together, our results show that
IL-13Ralpha ' is a novel functional component of the IL-4R system and that JAK1 and
JAK2 mediate IL-4 induced optimal activation of STAT6 in nonhematopoietic cells
Murata et al., Int Immunol 1998
:
The
Janus kinase (JAK)2 and Tyk2 were phosphorylated in
response to IL-4 or
IL-13 in sk559 and sk574 cell lines
Roy et al., J Biol Chem 1998
:
Induction of 15-lipoxygenase expression by
IL-13 requires tyrosine phosphorylation of
Jak2 and Tyk2 in human monocytes ... Our results suggest the novel finding that
IL-13 can
induce tyrosine phosphorylation of both
Jak2 and Tyk2 in primary human monocytes