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APOB — CTGF

Text-mined interactions from Literome

Yang et al., FASEB J 2004 (MAP Kinase Signaling System) : Tyrosine phosphorylation of the LDL receptor related protein (LRP) and activation of the ERK pathway are required for connective tissue growth factor to potentiate myofibroblast differentiation
Sohn et al., Kidney Int 2005 : The effects of LDL on CTGF and collagen I expression were carried out in rat mesangial cells ... The increase in CTGF and collagen I induced by LDL was significantly inhibited by neutralizing anti-TGF-beta antibodies ... Inhibition of p38 ( mapk ) or p42/44(mapk) activities did not affect LDL induced TGF-beta1, CTGF , and collagen I expression, whereas inhibition of c-Jun NH2-terminal kinase (JNK) suppressed LDL induced TGF-beta, CTGF, and collagen I expression
Sohn et al., Am J Physiol Heart Circ Physiol 2006 : To explore the mechanisms by which LDL regulates CTGF and collagen IV expression in HAECs, we determined first if CTGF and collagen IV are downstream targets for regulation by transforming growth factor-beta ( TGF-beta ) ... To assess whether the induction of CTGF in response to LDL is mediated via autocrine activation of TGF-beta, HAECs were treated with LDL for 24 h in the presence and absence of anti-TGF-beta neutralizing antibodies ( anti-TGF-beta NA ) ... The results demonstrated that the increase in CTGF induced by LDL was significantly inhibited by the anti-TGF-beta NA ... To investigate the upstream mediators of TGF-beta on activity of CTGF in response to LDL , HAECs were treated with LDL for 24 h in the presence and absence of cell-permeable MAPK inhibitors ... Inhibition of p38 ( mapk ) activities did not affect LDL induced TGF-beta1, CTGF , and collagen IV expression ... On the other hand, SP-600125, a specific inhibitor of c-Jun NH ( 2 ) -terminal kinase, suppressed LDL induced TGF-beta, CTGF, and collagen IV expression, and PD-98059, a selective inhibitor of p44/42(mapk), suppressed LDL induced TGF-beta and CTGF expression
El-Shewy et al., Mol Endocrinol 2012 (Diabetic Nephropathies...) : We recently reported that low-density lipoproteins (LDL) induced expression of CTGF in aortic endothelial cells ... Here, we have studied the mechanism by which LDL regulates CTGF expression in renal mesangial cells ... LDL induced CTGF expression was pertussis toxin sensitive and inhibited by dimethylsphinogsine down-regulation of SK1 and VPC23019 treatment ... Our data suggest that SK1 dependent S1P receptor transactivation is upstream of ERK1/2 and JNK and that all three steps are required for LDL regulated expression of CTGF in mesangial cells