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CDK2 — UCN

Text-mined interactions from Literome

Sugiyama et al., Cancer Res 1999 (Lung Neoplasms) : UCN-01 induced down-regulation of cyclin A level and CDK2 activity accompanied with its dephosphorylation in A549/UCN cells, but not in A549 cells
Usuda et al., Int J Cancer 2000 (Lung Neoplasms) : An inhibitory effect of UCN-01 on CDK2 activity, which is mediated by p21(Cip1)/CDK2 complex formation upon UCN-01 treatment, was observed in SBC-3 but not in SBC-3/UCN cells
Akiyama et al., Jpn J Cancer Res 1999 : Further studies revealed a correlation between UCN-01 induced G1-phase accumulation and reduction of cellular CDK2 kinase activity
Sampath et al., Mol Pharmacol 2002 : UCN-01 also had no effect on the association of p21 with Cdk2
Akiyama et al., Cancer Res 1997 (Carcinoma, Squamous Cell) : UCN-01 also increased the expression of the CDK inhibitor p27 protein after 24 h exposure at 260 and 520 nM
Shao et al., Cancer Res 1997 : In this study, we found that nanomolar concentrations of camptothecin ( CPT ), a topoisomerase I inhibitor, arrest or delay cell cycle progression during the S and G2 phases in p53 mutant human colon carcinoma HT29 cells and that UCN-01 abrogates the S-phase arrest or delay induced by CPT. Under these conditions, CPT increased cyclin A levels and cyclin A/cyclin dependent kinase 2 activity ... UCN-01 prevented the increase of cyclin A/cyclin dependent kinase 2 activity induced by CPT and enhanced Cdc2 kinase activity
Hsueh et al., Clin Cancer Res 1998 (Stomach Neoplasms) : UCN-01 , a protein kinase C/cyclin dependent kinase inhibitor , suppressed thymidylate synthase ( TS ) protein expression in a dose dependent manner with near complete suppression at 1 microM after a 24-h exposure in human gastric cancer cell line SK-GT5