◀ Back to IL10
IL10 — TGFB1
Text-mined interactions from Literome
Stearns et al., Clin Cancer Res 1999
(Neoplasm Metastasis...) :
ELISAs further showed that
TGF-beta1 expression
induced matrix metalloproteinases-2 (MMP-2) expression, whereas
IL-10 down-regulated MMP-2 expression while up regulating TIMP-1 in the transfected cells
Othieno et al., Infect Immun 1999
:
TGF-beta1 induced monocyte
IL-10 ( but not tumor necrosis factor alpha ) production ( by 70-fold, P < 0.02 ) and mRNA expression in the absence but not in the presence of PPD ... Thus,
TGF-beta1 and IL-10 together potentiate the downmodulatory effect on M. tuberculosis induced T-cell production of IFN-gamma, and TGF-beta1 alone
enhances IL-10 production
Ofosu-Appiah et al., J Autoimmun 1999
(Glomerulonephritis...) :
While the renal inflammatory cell infiltration and expression of interleukin-4 (IL-4) and
IL-10 were markedly suppressed, no local enhancement of
transforming growth factor-beta ( TGF-beta ) was
detected
David et al., Gene Ther 2000
:
Importantly, adenovirus derived
IL-10 modified the functional status of leukocytes by inducing a significant decrease in IFN-gamma production but significantly
increased transforming-growth factor beta 1 ( TGF-beta 1 ) expression within the grafts compared with those treated with Addl324
Schiött et al., Immunol Lett 2000
:
TGF-beta1 induced
IL-10 production, slightly decreased TNF-alpha production and decreased IFN-gamma production
Suberville et al., Eur Cytokine Netw 2001
:
Since differences exist between the transcriptional regulation of human and mouse IL-10, the studies reported here examined whether
TGF-beta1 up-regulated
IL-10 production by human monocytes/macrophages as well ... In addition,
TGF-beta1 suppressed induction of
IL-10 by three different stimuli other than PMA ...
TGF-beta1 inhibition of
IL-10 protein release was associated with proportional changes in IL-10 mRNA accumulation as assessed by quantitative kinetic ELISA PCR ... This would result from a decrease in IL-10 gene transcription as
TGF-beta1 did not
affect IL-10 mRNA stability, and TGF-beta1 limited the luciferase activity in cells transfected with reporter gene constructs containing 1,308 bp of the 5 ' non coding sequence of human IL-10 gene ... Thus, the present study provides the first evidence that
TGF-beta1 prevents
IL-10 production by human monocytic cells at a transcriptional level
von der Weid et al., Clin Diagn Lab Immunol 2001
:
In contrast,
IL-10 was maintained and
transforming growth factor beta ( TGF-beta ) was markedly
induced in a dose dependent manner
Yamauchi et al., Biochem Biophys Res Commun 2002
:
Furthermore, the involvement of TGF-beta1 in the inhibition of IL-10 release by TSP-1 was indicated by the facts that ( i ) TSP-1 induced activation of
TGF-beta1 produced by the U937 cells, ( ii ) exogenously added TGF-beta1 inhibited IL-10 release, and ( iii ) antibody against TGF-beta1
blocked the inhibition of
IL-10 release by TSP-1
Ortegel et al., Lung Cancer 2002
(Carcinoma, Non-Small-Cell Lung...) :
When added to TIL cultures stimulated with anti-CD3+IL-2, IL-4 and
IL-10 enhanced and
TGF-beta1 suppressed the development of TIL cytolytic activity against autologous tumor cells
Mizrachi-Nebenzahl et al., Clin Exp Immunol 2003
(Disease Progression...) :
Analysis of mRNA expression of cytokines in the spleen revealed no alterations in tumour necrosis factor (TNF)-alpha,
transforming growth factor ( TGF ) -beta , interleukin (IL)-12 and interferon (IFN)-gamma and
induction of
IL-10 and IL-4
Bry et al., Am J Obstet Gynecol 1992
(Obstetric Labor, Premature) :
Human amnion cells in monolayer culture were treated with
interleukin-1 , tumor necrosis factor, or vehicle in the
presence or absence of
transforming growth factor-beta
Kitani et al., J Exp Med 2003
(Fibrosis) :
In addition, using a self inactivating retrovirus luciferase reporter construct we showed that
TGF-beta1 induces Smad4, which then binds to and
activates the
IL-10 promoter ... Taken together, these findings suggest that the
induction of
IL-10 by
TGF-beta1 is not fortuitous, but instead fulfills important requirements of TGF-beta1 function after its secretion by regulatory T cells
Barbarin et al., Am J Respir Cell Mol Biol 2004
(Disease Models, Animal...) :
Thus the net profibrotic activity of
IL-10 in vivo appears to be
mediated by its ability to stimulate the expression of the profibrotic cytokine
TGF-beta1 while suppressing the expression of cyclooxygenase-2 and thus production of the antifibrotic eicosanoid PGE2
Gunnlaugsdottir et al., Int Immunol 2005
(Necrosis) :
Interestingly,
TGF-beta1 induced
IL-10 and TNFalpha secretion
Méndez-Dávila et al., J Endocrinol Invest 2004
(Osteoporosis) :
We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and
interleukin-1 stimulated interleukin (IL)-6,
transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Xiong et al., Zhonghua Wai Ke Za Zhi 2005
(Liver Cirrhosis, Experimental) :
To investigate the
effect of
interleukin-10 (IL-10) on the expression of
transforming growth factor-beta(1) ( TGFbeta(1) ) and platelet derived growth factor ( PDGF ) in hepatic stellate cells (HSC) during liver injury
Sashinami et al., Cytokine 2006
(Salmonella Infections, Animal) :
Treatment of monoclonal antibodies against cytokines showed that IFN-gamma and
interleukin 10 (IL-10) were involved in maintenance of growth of S. Typhimurium mutant on day 10 after infection, and IFN-gamma, TNF-alpha and
transforming growth factor-beta ( TGF-beta ) were
involved in maintenance of growth of this bacterium on day 30 after infection
Shi et al., World J Gastroenterol 2006
(Liver Cirrhosis) :
To study the
effect of
interleukin-10 (IL-10) on the expression of
transforming growth factor beta1 ( TGF-beta1 ) in hepatic fibrosis rats and the anti-fibrotic role of exogenous IL-10
Babel et al., J Nephrol 2006
(Diabetic Nephropathies...) :
Since TNF-alfa and
IL-10 are involved in regulation of inflammation, and
TGF-beta 1 can
induce fibrosis and renal insufficiency - dominant features of end-stage renal disease ( ESRD ), we explored the hypothesis that polymorphisms of these cytokine genes may be possible genetic susceptibility factors for the progression of renal failure
Fueki et al., Respiration 2007
:
Interleukin-10 regulates
transforming growth factor-beta signaling in cultured human bronchial epithelial cells
Pyrovolaki et al., Eur J Haematol 2007
(Neutropenia) :
Transforming growth factor-beta1 affects
interleukin-10 production in the bone marrow of patients with chronic idiopathic neutropenia ... Excessive production of
TGF-beta1 within the BM microenvironment of CIN patients
results in downregulation of
IL-10 and reduction of myeloid progenitor cells
Zhao et al., J Huazhong Univ Sci Technolog Med Sci 2007
:
Effect of
TGF-beta1 on the expression of IL-12, IL-15, IL-18, IL-4 and
IL-10 in heart transplantation rejection in rats
Perez et al., J Immunol 2008
(Diabetes Mellitus, Type 1) :
Preferential costimulation by CD80 results in
IL-10 dependent
TGF-beta1 ( + ) -adaptive regulatory T cell generation ... These observations demonstrate not only that CD80 preferentially binds to CTLA-4 but also that interaction during Ag presentation can result in
IL-10 dependent
TGF-beta1 ( + ) regulatory T cell induction, reinstating the potential of approaches to preferentially engage CTLA-4 through CD80 during self-Ag presentation in suppressing autoimmunity
Layh-Schmitt et al., Curr Opin Rheumatol 2008
(Spondylarthropathies) :
In mice,
transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages
promoting interleukin-17 production
Yang et al., Zhonghua Nan Ke Xue 2009
(Autoimmune Diseases...) :
IL-10 could relieve inflammatory infiltration of the prostate tissue and
inhibit the expressions of TNF-alpha and
TGF-beta1 in EAP rats, which is suggestive of its therapeutic efficacy for autoimmune prostatitis
Zhang et al., Clin Neurol Neurosurg 2010
(Autoimmune Diseases...) :
IFNbeta inhibited IL-1beta, IL-23 and
transforming growth factor ( TGF ) -beta ( which induce Th17 cell differentiation ), and
induced IL-27, IL-12p35 and
IL-10 ( which suppress it ) in dendritic cells (DCs) and B-cells
Díaz-Valdés et al., Cancer Res 2011
(MAP Kinase Signaling System...) :
Induction of monocyte chemoattractant protein-1 and
interleukin-10 by
TGFbeta1 in melanoma enhances tumor infiltration and immunosuppression
Link et al., J Neuroimmunol 1995
(Inflammation...) :
Transforming growth factor-beta 1 suppresses autoantigen induced expression of pro-inflammatory cytokines but not of
interleukin-10 in multiple sclerosis and myasthenia gravis
Link et al., Acta Neurol Scand Suppl 1994
(HIV Infections...) :
Recombinant ( r )
TGF-beta 1 dose-dependently
suppressed MBP induced upregulation of the proinflammatory cytokines IFN-gamma, IL-4, IL-6, tumor necrosis factor-alpha, ( TNF-alpha ), TNF-beta and perforin, but not of the immunosuppressive and probably advantageous
IL-10
Matthes et al., Eur J Immunol 1995
:
On the other hand, and in contrast to the suppression of B cell proliferation and Ig secretion, the basal or the
IL-6/IL-10 stimulated Ig secretion of nonproliferating cells was not
inhibited by recombinant
TGF-beta 1
Kitani et al., J Immunol 1994
:
In contrast, SAC plus
TGF-beta 1 does not induce C alpha 2 mature transcripts, even in the
presence of exogenous
IL-10 ; such transcripts are induced, however, by T cell stimuli such as anti-CD40 ( presented by CDw32 transfected L cells ) in the presence of TGF-beta 1/IL-10 or by PWM activated T cells
Van Vlasselaer et al., J Cell Biol 1994
:
Interleukin 10 inhibits
transforming growth factor-beta ( TGF-beta ) synthesis required for osteogenic commitment of mouse bone marrow cells
Reinhold et al., J Interferon Cytokine Res 1995
:
Transforming growth factor beta 1 inhibits
interleukin-10 mRNA expression and production in pokeweed mitogen stimulated peripheral blood mononuclear cells and T cells ... Here we have analyzed the
effects of
TGF-beta 1 on
IL-10 and IL-1RA production in pokeweed mitogen stimulated peripheral blood mononuclear cells ( PBMC ) and purified T lymphocytes ... We show in these systems that
TGF-beta 1 at a concentration of 10 ng/ml significantly
suppresses both
IL-10 mRNA expression and IL-10 production ... IL-2 and IL-6 were capable of abolishing the
effect of
TGF-beta 1 on DNA synthesis and production of
IL-10 by T lymphocytes in an additive manner
Xu et al., Kidney Int 1995
:
Our investigation demonstrated that : ( a ) intragraft expression of IL-10 mRNA and IL-2 mRNA are significant correlates of acute rejection ; ( b ) IL-4, IL-7, IFN-gamma and TGF-beta 1 mRNA expression do not correlate with acute rejection ; and ( c )
IL-10 does not
prevent in vivo expression of IFN-gamma, IL-2, IL-7, or
TGF-beta 1
Kumar et al., J Cell Physiol 1996
:
Induction of
interleukin-1 and interleukin-8 mRNAs and proteins by
TGF beta 1 in rat lung alveolar epithelial cells
Marth et al., Eur J Immunol 1997
:
Regulation of
transforming growth factor-beta production by
interleukin-12
Giacalone et al., Exp Dermatol 1998
(Pemphigoid, Bullous) :
Although a clear explanation of this phenomenon is lacking, the data presented in this report agree with a strong decrease of IL-7 production at the local level ( keratinocyte is known to produce IL-7 and the latter is known to be
down-regulated by
IL-10 , and in other models also by
TGF-beta1 and IL-4, whose levels are elevated in BP BFs ) as opposed to an increased peripheral release of the same modulator
Fulton et al., J Infect Dis 1998
:
Regulation of
interleukin-12 by interleukin-10,
transforming growth factor-beta , tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra