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ADAM10 — CDH1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: ADAM10 (ADAM10) → E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1_JUP-CTNNA1-CTNND1) (modification, activates)
  Maretzky et al., Proc Natl Acad Sci U S A 2005, Wild-Bode et al., J Biol Chem 2006, Huguenin et al., PloS one 2008, Dittmer et al., Cell Mol Life Sci 2009, Wheelock et al., J Cell Biochem 1987
  Evidence: mutant phenotype, assay
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: ADAM10 (ADAM10) → sE-cad (CDH1) (modification, activates) Maretzky et al., Proc Natl Acad Sci U S A 2005, Wild-Bode et al., J Biol Chem 2006, Huguenin et al., PloS one 2008, Dittmer et al., Cell Mol Life Sci 2009, Wheelock et al., J Cell Biochem 1987
  Evidence: mutant phenotype, assay
• Reactome Reaction: ADAM10 → CDH1 (reaction) Maretzky et al., Proc Natl Acad Sci U S A 2005, Najy et al., J Biol Chem 2008*

Text-mined interactions from Literome

Maretzky et al., J Invest Dermatol 2008 (Blister...) : ADAM10 mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis ... Here, we reveal that the disintegrin and metalloprotease ADAM10 is critically involved in regulating E-cadherin cell-surface expression in cultured primary human keratinocytes and in diseased human skin ... Our data suggest that ADAM10 mediated E-cadherin proteolysis leads to the impaired cohesion of keratinocytes observed in eczematous dermatitis and provide previously unreported insights into the understanding of the molecular mechanisms involved in inflammatory diseases with loss in epithelial integrity
Klessner et al., Mol Biol Cell 2009 : ADAM9 and 15 silencing also impaired Dsg2 processing, supporting the idea that this desmosomal cadherin can be regulated by multiple ADAM family members
Yue et al., BioMed research international 2013 (Carcinoma, Hepatocellular...) : The Western blotting results suggest that the down-regulation of ADAM10 expression increases E-cadherin protein levels