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PIGR — TNF

Text-mined interactions from Literome

Takenouchi-Ohkubo et al., Immunogenetics 2000 : Stimulation by TNF-alpha significantly activated the pIgR gene promoter, as a 775-bp upstream region of the pIgR gene increased luciferase gene expression in cells treated with TNF-alpha ... These data indicated that pIgR gene expression induced by TNF-alpha is transcriptionally regulated via activation of NF-kappaB
Schjerven et al., J Immunol 2001 : The proinflammatory cytokine TNF-alpha is a key mediator of host responses to infections, and it can stimulate protein synthesis dependent transcriptional up-regulation of pIgR/SC in the HT-29 intestinal adenocarcinoma cell line ... Thus, DNA elements located > 4 kb apart were found to cooperate in TNF-alpha induced pIgR/SC up-regulation
Schjerven et al., J Immunol 2004 (Adenocarcinoma...) : TNF activates a proinflammatory gene repertoire in mucosal epithelial cells and also enhances pIgR expression ... In this study we show that TNF induced up-regulation of the human pIgR critically depends on an NF-kappa B site and flanking sequences within a 204-bp region of the first intron in the pIgR gene, a region largely overlapping with a recently characterized IL-4-responsive enhancer
Hamada et al., Immunology 1991 : Additional evidence of specificity of the TNF-alpha effect on the Fc gamma IBS was that TNF-alpha did not affect expression of the polymeric immunoglobulin receptor ( secretory component ), whereas IFN-gamma increased it
Takenouchi-Ohkubo et al., Immunology 2008 : These data suggest that TNF-alpha mediated pIgR expression is negatively regulated by ERK pathway, which is independent of NF-kappaB
Hermsen et al., Surg Infect (Larchmt) 2008 (Wounds and Injuries) : Tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) stimulate the production of polymeric immunoglobulin receptor (pIgR) , the protein required to transport immunoglobulin A (IgA) to mucosal surfaces
Jonker et al., J Trauma 2010 (Pneumonia, Ventilator-Associated...) : Tumor necrosis factor (TNF)-a and interleukin (IL)-1ß stimulate the production of polymeric immunoglobulin receptor , the protein required to transport immunoglobulin A (IgA) to mucosal surfaces
Bruno et al., Mucosal Immunol 2011 : Inhibition of mitogen activated protein kinases reduced the induction of IL-8, but enhanced the induction of pIgR by TNF and TLR signaling