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GIPC2 — IGF1
Text-mined interactions from Literome
Muders et al., Cancer Res 2006
(Adenocarcinoma...) :
Here, we described GIPC expression in different human pancreatic adenocarcinoma ( PCA ) cell lines and we examined the
role of
GIPC in the regulation of
IGF-IR protein levels in PCA ... Interestingly, inhibition of
GIPC expression by RNA interference
led to reduced
IGF-IR protein levels and a subsequent decrease in proliferation of PCA cells
Paek et al., Mol Cells 2011
(Colonic Neoplasms) :
Taken together, these data suggest that
GIPC is
involved in
IGF-1 signaling leading to ZNF143 expression through the regulation of ROS production, which may play a role for colon cancer tumorigenesis