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GZMB — IL15

Text-mined interactions from Literome

Tamang et al., Cytokine 2006 : Induction of granzyme B and T cell cytotoxic capacity by IL-2 or IL-15 without antigens : multiclonal responses that are extremely lytic if triggered and short lived after cytokine withdrawal ... To our surprise, both IL-2 and IL-15 induced not only proliferation, but also profound granzyme B and lytic capacity from CD8+ T cells in the absence of antigen or TCR-stimulation
Bendle et al., PloS one 2007 : In contrast, IL-15 and IL-21 only restored the expression of CD43 and granzyme-B , but not IFN-gamma production
Cai et al., J Immunol 2009 (Cytomegalovirus Infections) : We detected granzyme B and C expression in CD4 ( + ) and CD8 ( + ) T cells activated with CD3/CD28 beads or MLRs. Stimulation of NK cells in vitro with IL-15 also induced expression of both granzymes
Marshall et al., J Immunol 2010 (Arenaviridae Infections) : IL-12, IL-15 , IL-18, and IFN-gamma were not individually required for sensitization to produce IFN-gamma, but IL-15 was required for upregulation of granzyme B
Schneider et al., J Immunol 2011 (Multiple Sclerosis) : Furthermore, we showed that IL-15 expressed by B cells and monocytes is sufficient and functional, enhancing granzyme B production by CD8 T cells upon coculture
Wang et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2012 : IL-15 up-regulated the expression of granzyme B on NK cells
Salvucci et al., Eur J Immunol 1996 : Northern blot analysis indicated that the IL-4 regulatory effect on NK lytic function was associated with its capacity to down-regulate granzyme B and perforin gene transcription in response to IL-15 and its failure to affect the expression of both gene 's in response to IL-12