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CTGF — ILK
Text-mined interactions from Literome
Liu et al., Clin Chim Acta 2007
:
Role of ERK1/2 and PI3-K in the regulation of
CTGF induced
ILK expression in HK-2 cells ... In this study, we investigated the role of extracellular regulating kinase 1/2 ( ERK1/2 ) and phosphatidylinositol 3-kinase (PI3-K) in the
regulation of
ILK expression by
connective tissue growth factor (CTGF) in HK-2 cells ... Induction of
ILK in
response to
CTGF was studied at the mRNA level by real-time PCR and protein by immunoblotting ... Chemical inhibitors were used to assess the role of MEK/ERK1/2, PI3-K, and P38 MAPK signaling pathways in
induction of
ILK by
CTGF ...
CTGF induced
ILK protein expression in HK-2 cells in a time- and dose dependent manner ...
CTGF induced
ILK expression was partially reduced by inhibiting ERK1/2 and PI3-K activation ...
CTGF induces the expression of
ILK protein in HK-2 cells ... Inhibiting
CTGF induced
ILK by targeting PI3-K and/or MEK/ERK1/2 signaling pathways could be of therapeutic value in renal fibrosis
Wu et al., Am J Respir Cell Mol Biol 2010
(Pulmonary Fibrosis) :
Furthermore, overexpression of
CTGF increased
integrin linked kinase expression, activated its downstream signaling target, Akt, as well as increased mRNA expression of fibronectin
Dai et al., J Cell Biochem 2012
(Diabetic Nephropathies) :
Of note, the upregulation of
ILK induced by high glucose was partially
blocked by the inhibition of
CTGF