Hassona et al., Am J Physiol Heart Circ Physiol 2010
(Disease Models, Animal...) :
The activation of Rho/ROCK led to the inhibition of endothelial nitric oxide synthase expression ( 39 + or - 5.4 % ; P < 0.05 ) and phosphorylation ( 35 + or - 4.5 % ; P < 0.05 ) but also an increase in myosin light chain 20 phosphorylation ( 372 %, P < 0.05 )
Soliman et al., Am J Physiol Heart Circ Physiol 2012
(Diabetes Mellitus, Experimental...) :
Inhibition of RhoA and ROCK markedly attenuated the diabetes induced increases in PKCß ( 2 ) activity and iNOS and RhoA expression in diabetic cardiomyocytes, while having no effect in control cells