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IL6 — INS

Text-mined interactions from Literome

Shimizu et al., J Endocrinol 2000 : Interleukin-6 increases insulin secretion and preproinsulin mRNA expression via Ca2+ dependent mechanism ... The present studies were undertaken to investigate the mechanism of IL-6 induced stimulation of insulin secretion in HIT-T 15 cells ... The addition of 100 and 1000 nM nifedipine significantly attenuated the stimulatory effects of 100 pg/ml IL-6 on insulin secretion ... IL-6 increased insulin gene promoter activity of fragments A ( -2188 to +337 bp ) and B ( -1782 to +270 bp ) but not fragments C ( -1275 to +270 bp ), D ( -1138 to +270 bp ), E ( -880 to +236 bp ) or F ( -356 to +252 bp )
Mabley et al., Br J Pharmacol 2001 (Diabetes Mellitus, Experimental) : In vitro the cytokine combination ; interleukin-1beta , tumor necrosis factor-alpha and interferon-gamma inhibited glucose stimulated insulin secretion from isolated rat islets of Langerhans and decreased RIN-5F cell viability
Senn et al., Diabetes 2002 (Insulin Resistance) : Here, we present data that IL-6 can inhibit insulin receptor (IR) signal transduction and insulin action in both primary mouse hepatocytes and the human hepatocarcinoma cell line, HepG2
Senn et al., J Biol Chem 2003 (Insulin Resistance) : Suppressor of cytokine signaling-3 ( SOCS-3 ), a potential mediator of interleukin-6 dependent insulin resistance in hepatocytes
Flower et al., Cytokine 2003 : TNFalpha and insulin induced IL-6 production from PBC, but had no effect on adipocytes
Fasshauer et al., Horm Metab Res 2003 (Insulin Resistance) : Interleukin (IL)-6 mRNA expression is stimulated by insulin , isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes
Doherty et al., Cytokine 1992 : ACTH and insulin increased supernatant levels of IL-6 produced in response to LPS without altering available transcripts
Campos et al., Mol Cell Biol 1992 (Acute-Phase Reaction...) : Transfection of CAT gene constructs containing increasing lengths of heptaglobin gene 5 ' flanking sequences indicated that insulin inhibition of IL-6 stimulation required the presence of the region from -4100 to -1030
Weigert et al., J Biol Chem 2004 : Insulin , high glucose concentrations, or unsaturated FFAs did not activate IL-6 expression
Bruce et al., Am J Physiol Endocrinol Metab 2004 (Insulin Resistance) : Furthermore, in the presence of insulin , IL-6 reduced the esterification of FA to triacylglycerol by 22 % ( P < 0.05 )
Rabinovitch et al., Diabetologia 1992 : The individual cytokines, interleukin 1 ( 1 U/ml ), tumour necrosis factor ( 10 ( 2 ) U/ml ), and interferon gamma ( 10 ( 2 ) U/ml ) inhibited insulin release but did not increase islet malondialdehyde levels
Gao et al., Zhonghua Shao Shang Za Zhi 2004 (Burns) : The plasma levels of PGE2, TXB2, TNF-alpha and IL-6 significantly decreased and insulin , rhGH and IGF-1 obviously increased when compared with those in group B
Rieusset et al., Diabetes 2004 (Diabetes Mellitus...) : We investigated whether IL-6 could inhibit insulin signaling in human skeletal myotubes and whether suppressor of cytokine signaling 3 ( SOCS-3 ) could be related to insulin resistance in vivo in humans
Rotter Sopasakis et al., Diabetologia 2004 (Hyperinsulinism...) : These data further underscore the importance of the chronic, and potentially tissue-specific effects of IL-6 on insulin signalling and action
Fain et al., Metabolism 2005 : Insulin enhances vascular endothelial growth factor, interleukin-8 , and plasminogen activator inhibitor 1 but not interleukin-6 release by human adipocytes
Yelich et al., Pancreas 1992 : Effects of endotoxin and interleukin-1 on glucagon and insulin secretion from the perfused rat pancreas
Westerbacka et al., Diabetologia 2006 (Body Weight...) : The expression of ` insulin-resistance genes ' HSD11B1 and IL6 was increased by insulin in the insulin-resistant group, but insulin failed to increase HSD11B1 expression in the insulin-sensitive group ... IL6 expression increased significantly more in response to insulin in the insulin-resistant than in the insulin-sensitive group
Inoue et al., Cell Metab 2006 (Insulin Resistance) : This effect of insulin was mediated by the hormone 's effects in the brain, and the increase in hepatic IL-6 induced by the brain-insulin action is essential for the activation of STAT3
Zawalich et al., Mol Cell Endocrinol 1991 : Influence of staurosporine, nitrendipine and monooleoylglycerol on interleukin-1 induced insulin secretion and phosphoinositide hydrolysis
Flores et al., Diabetes 2006 : The regulatory role of interleukin (IL)-6 in mediating the increase in leptin and insulin sensitivity in hypothalamus was also investigated
Johannesen et al., Acta Endocrinol (Copenh) 1990 : During beta-cell stimulation with tolbutamide, interleukin 1 beta caused inhibition of insulin accumulation to 36 +/- 9 % of control
Könner et al., Cell Metab 2007 (Body Weight...) : These mice also exhibited reduced insulin stimulated hepatic interleukin-6 expression and increased hepatic expression of glucose-6-phosphatase
Kim et al., J Biol Chem 2008 (Carcinoma, Hepatocellular...) : IL-6 activates S6K1 in these cells, but unexpectedly, S6K1 is not involved in IL-6 inhibition of insulin signaling, since the effect of IL-6 persists in cells with drastically reduced S6K1 levels induced by RNA interference, suggesting that the function of mTOR signaling is through a mechanism different from the prevailing model of S6K1 phosphorylation of insulin receptor substrate-1 ... Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by mTOR upon IL-6 stimulation and that STAT3 is required for IL-6 inhibition of insulin signaling
Kidd et al., J Pharmacol Exp Ther 2008 (Disease Models, Animal...) : The PI3K inhibitor wortmannin abolished the insulin mediated activation of Akt and the reduction of chemokine and interleukin-6 levels
LaPensee et al., Endocrinology 2008 (MAP Kinase Signaling System) : Insulin stimulates interleukin-6 expression and release in LS14 human adipocytes through multiple signaling pathways ... Using LS14, a newly developed human adipocyte cell line, our objective was to determine the mechanisms by which insulin stimulates IL-6 production and release in preadipocytes ... Insulin increased IL-6 gene expression and secretion in a time- and dose dependent manner ... Insulin decreased cyclic AMP ( cAMP ) but increased cyclic GMP ( cGMP ) levels, and IL-6 expression/release was stimulated by a cGMP analog ... Insulin also activated the MAPK signaling pathway, and its blockade prevented the insulin stimulated increases in IL-6 cell content and release, but not IL-6 gene expression ... These data suggest that the stimulatory effects of insulin on IL-6 release involve several interrelated components : transcription, intracellular releasable pool, and secretion, which are differentially regulated and, thus, determine the size of the releasable pool of IL-6 ... Insulin induced IL-6 gene expression is mediated by cGMP/cyclic GMP dependent protein kinase/cAMP response element binding protein, whereas MAPK is involved in the insulin stimulated IL-6 synthesis/release
Shimizu et al., J Endocrinol Invest 1991 : Involvement of interleukin-1 in the inhibition of in vivo insulin release : possible role of adrenal glands
Krag et al., Clin Endocrinol (Oxf) 2009 (Insulin Resistance) : Peroxisome proliferator activated receptor gamma ( PPAR ) agonism reduces the insulin stimulated increase in circulating interleukin-6 in GH replaced GH-deficient adults
Yuen et al., Diabetes 2009 : The effect of IL-6 with and without insulin on AMPK, insulin , and eNOS signaling in and nitric oxide ( NO ) release from human aortic endothelial cells ( HAECs ) was examined
Kim et al., Vitam Horm 2009 (Inflammation...) : Herein we review the in vivo and in vitro studies that have examined the role of IL-6 in insulin signaling and glucose metabolism in the insulin target tissues : liver, adipose, and skeletal muscle
Muscelli et al., Horm Metab Res 2009 (Hyperinsulinism) : We assessed the acute effect of glucose and insulin on soluble CD40 ligand ( sCD40L ), IL-6 , and P-selectin levels, evaluating their relationship with insulin sensitivity in normal glucose tolerance subjects ( NGT )
Ruge et al., Metabolism 2009 (Diabetes Mellitus, Type 2...) : Insulin induced rise in IL-6 correlated negatively to BMI ( P = .001 ), waist to hip ratio ( P = .05 ), and baseline ( fasting ) insulin ( P = .03 ) and IL-6 ( P = .02 ) levels and positively to insulin stimulated glucose uptake in isolated adipocytes ( P = .07 )
Uehara et al., Eur J Pharmacol 1991 (Hyperinsulinism) : With the aim of studying the mechanism by which peripherally injected interleukin-1 increases the serum levels of insulin in conscious rats, the effects of indomethacin, a cyclooxygenase inhibitor, on interleukin-1 induced hyperinsulinemia were examined using male Wistar rats implanted with intra-atrial cannulas ... It was also found that this insulin response to interleukin-1 was dose related ... Pretreatment with indomethacin ( 3 mg/kg body weight ), however, completely blocked the interleukin-1 induced stimulation of insulin secretion
Rojas et al., Oncogene 2011 (Cell Transformation, Neoplastic...) : Moreover, we find that paracrine IL-6 stimulates the autocrine IL-6 loop and autocrine activation of insulin-like type I growth factor receptor ( IGF-IR ) to confer the tumorigenic property and also that activation of signal transducer and activator of transcription 3 ( STAT3 ) is critical in these processes
Suzuki et al., Diabetes 2011 : Interleukin-6 enhances glucose stimulated insulin secretion from pancreatic beta-cells : potential involvement of the PLC-IP3 dependent pathway ... However, the effects of IL-6 on insulin secretion from pancreatic ß-cells are controversial ... First, to examine the effects of IL-6 on in vivo insulin secretion, we expressed IL-6 in the livers of mice using the adenoviral gene transfer system ... Furthermore, using pharmacological inhibitors and small interfering RNAs, we studied the intracellular signaling pathway through which IL-6 may affect insulin secretion from MIN-6 cells
Buschard et al., Autoimmunity 1990 (Diabetes Mellitus, Type 1) : Both sources of IL-6 stimulated insulin secretion over a period of 6 days ( P less than 0.01 ), whereas the levels of insulin within the islets were unaffected ... We conclude that human IL-6 stimulates insulin production and secretion in vitro and induces similar ultrastructural changes in beta-cells as does IL-1 beta
Thompson et al., PloS one 2012 : Plasma IL-6 concentrations increase in response to glucose and insulin , consistent with both an early glucose dependent response ( detectable at 1-2 hours ) and a late insulin dependent response ( detectable after 2 hours )
Southern et al., Biochem J 1990 : However, IL-1 beta and IL-6 were found to inhibit insulin secretion in an additive manner ... These results suggest that IL-6 inhibits insulin secretion in a manner distinct from that of IL-1 beta, and that IL-6 is unlikely to mediate the inhibitory effects of IL-1 beta or TNF-alpha on rat islets of Langerhans
da Silva Krause et al., J Endocrinol 2012 : Our data have demonstrated that IL6 can stimulate ß-cell dependent insulin secretion via direct cell based mechanisms
Parazzoli et al., J Biol Chem 2012 : Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1ß induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets
Melloni et al., Nutrition 2013 : Under the proliferation conditions, insulin plus palmitic acid promoted a significant increase in the release of interleukin-6 , keratinocyte derived chemokine ( KC ) /chemokine ligand-1 ( CXCL-1 ), monocyte chemotactic protein-1 (MCP-1), and regulated and normal T cells expressed and presumably secreted ( RANTES ) by 3T3-L1 preadipocytes
Bailey et al., ISRN endocrinology 2013 : Interleukin-6 (IL-6) levels are elevated in CKD and impair insulin signaling at the level of IRS-1
Manning et al., PloS one 2013 (Overweight) : These data show that plasma IL-6 concentrations did not decrease during isoglycemic, intravenous glucose administration suggesting that the markedly higher circulating insulin levels and/or gut related factors may mediate the acute decrease in plasma IL-6 after oral glucose intake in overweight/obese subjects
Helqvist et al., Acta Endocrinol (Copenh) 1989 : Treatment with 10 mumol/l of verapamil ( a potent blocker of the voltage dependent calcium channel ) tended to suppress the inhibitory effect of interleukin 1 on insulin release from rat islets, suggesting protection against cytotoxicity
Hansen et al., Biomed Biochim Acta 1988 : Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets
Sandler et al., Endocrinology 1987 : Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets
Rabinovitch et al., Diabetologia 1994 : The individual cytokines, interleukin 1 ( 10 U/ml ), tumour recrosis factor ( 10 ( 3 ) U/ml ) and interferon gamma ( 10 ( 3 ) U/ml ) inhibited insulin release from rat islets, but did not cause DNA fragmentation or destroy islet cells ; by contrast, combination of the three cytokines induced DNA fragmentation and islet-cell death
Vara et al., Pancreas 1994 : Interleukin-1, tumor necrosis factor, and interleukin-6 inhibit insulin release and may be cytotoxic to isolated pancreatic islets
Sun et al., Zhonghua Yi Xue Za Zhi 1993 : IL-6 promoted the insulin secretion of islets dose-dependently
Csaba et al., Cytokine 1995 : Insulin binding to the plasma membrane of Tetrahymena was increased by IL-6 but not by IL-3 after 24 hours, and this enhancement appeared even after one hour incubation
Geng et al., Zhonghua Yi Xue Za Zhi 1996 (Diabetes Mellitus, Experimental) : Ins could promote 3H-TdR in corporation and increase the production of IL-6 , and captopril inhibited 3H-TdR in corporation and decrease the production of TNF
Campos et al., J Biol Chem 1996 : Insulin mediated a similar magnitude reduction in the amount of mRNA encoding the IL-6 receptor alpha subunit and IL-6 binding activity
Atlan-Gepner et al., Diabetes Care 1996 (Atrophy...) : The production of TNF-alpha and IL-6 by the macrophages of the patient in presence of insulin were dramatically increased in comparison with control subjects
Huppertz et al., Diabetologia 1996 : The effects of insulin, insulin-like growth factor (IGF)-I, platelet derived growth factor ( PDGF ), interleukin (IL)-6 and interferon-gamma on 2-deoxyglucose uptake and insulin receptor substrate (IRS)-1 phosphorylation were compared in 3T3-L1 cells at confluence and after differentiation to the adipocyte-like phenotype
Franchimont et al., Endocrinology 1997 : We tested the effects of IL-6 and its soluble receptor (IL-6sR) on the expression of insulin-like growth factor (IGF)-I and IGF-II in cultured osteoblast enriched cells from fetal rat calvariae ( Ob cells )
Wadt et al., Diabetes 1998 : Interleukin-6 (IL-6) alone or in combination with IL-1beta inhibits glucose stimulated insulin release from isolated rat pancreatic islets by unknown mechanisms ... IL-6 ( 10 ng/ml ) also potentiated IL-1beta mediated NO synthesis and inhibition of insulin release, whereas beta-nerve growth factor (NGF) ( 5 or 50 ng/ml ) had no effect