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CASP8 — PEA15
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PEA15
—
CASP8
(direct interaction, pull down)
Kitsberg et al., J Neurosci 1999*
-
IRef Biogrid Interaction:
PEA15
—
CASP8
(physical association, affinity chromatography technology)
Condorelli et al., Oncogene 1999*
-
IRef Hprd Interaction:
CASP8
—
PEA15
(in vitro)
Condorelli et al., Oncogene 1999*, Kitsberg et al., J Neurosci 1999*
-
IRef Hprd Interaction:
CASP8
—
PEA15
(in vivo)
Condorelli et al., Oncogene 1999*, Kitsberg et al., J Neurosci 1999*
-
IRef Ophid Interaction:
CASP8
—
PEA15
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Estellés et al., Dev Biol 1999
:
The phosphoprotein protein
PEA-15 inhibits Fas- but
increases TNF-R1 mediated
caspase-8 activity and apoptosis
Trencia et al., J Biol Chem 2004
:
In addition,
ped/pea-15 expression
blocked Omi/HtrA2 co-precipitation with the caspase inhibitor protein XIAP and
caspase 3 activation
Böck et al., J Biol Chem 2010
(Brain Neoplasms...) :
The mechanism by which
PEA-15 inhibits
caspase activation and increases ERK ( extracellular regulated kinase ) activity is well characterized