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DNMT3B — MYLIP
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Duursma et al., RNA 2008
:
Here we show that human
miR-148 represses
DNA methyltransferase 3b (Dnmt3b) gene expression through a region in its coding sequence ... Whereas overexpression of miR-148 results in decreased DNMT3b1 expression, short-hairpin RNA mediated
miR-148 repression
leads to an increase in
DNMT3b1 expression
Takada et al., RNA 2009
:
Potential
role of
miR-29b in modulation of Dnmt3a and
Dnmt3b expression in primordial germ cells of female mouse embryos ... Transcripts of the human genes for the de novo methyltransferases DNMT3A and DNMT3B have been identified as targets of miR-29b, and we found that mouse
miR-29b also negatively
regulates Dnmt3a and
Dnmt3b expression in luciferase reporter assays
Chavali et al., Biochem Biophys Res Commun 2012
(Diabetes Mellitus...) :
We tested the hypothesis that
miR-133a regulates DNA methylation by inhibiting Dnmt-1 ( maintenance ) and
Dnmt-3a and -3b ( de novo ) methyl transferases in diabetic hearts by using Ins2 ( +/- ) Akita ( diabetic ) and C57BL/6J ( WT ), mice and HL1 cardiomyocytes ... The results revealed that
miR-133a is inhibited but
Dnmt-1 and -3b are
induced in Akita suggesting that attenuation of miR-133a induces both maintenance ( Dnmt-1 ) - and de novo - methylation ( Dnmt-3b ) in diabetes
Wu et al., BMC genomics 2013
:
This phenomenon was observed not only in the hsa-miR-148a regulated
DNMT3B gene, but also in many target genes
regulated by
hsa-miR-124 , hsa-miR-1, and hsa-miR-181a
Tan et al., Biochem Biophys Res Commun 2013
(Carcinoma, Non-Small-Cell Lung...) :
The expression of miR-29a and
miR-29b was partially
regulated by DNMT3A and
DNMT3B in a positive feedback loop