Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
TYK2
→
NRG1
(increases)
Liu et al., Am J Respir Cell Mol Biol 2002* Evidence: Treatment of cells with NGR-1 showed a 7 and 14 fold increase in JAK3 and TYK2 phosphorylation after 10 mins and rapidly decreased to their basal level, but when treated with 2C4, a specific antibody of HER-2 there was a total abrogation in this phosphorylation, indicating that HER2 receptor is required for NGR-1 induced activation of JAK3 and TYK2 phosphorylation.