Mizuochi et al., J Immunol 1988
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If IL1 acts directly on lymphokine secreting T cells or on the APC with which they interact is not yet certain
Wingren et al., Cell Immunol 1996
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Gene targeting of IL-1 to the secretory or cytoplasmic pathway may be useful for elucidating the role of IL-1 in T cell-APC interactions, avoiding cell death of the producer cells
Morein et al., Dev Biol Stand 1998
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Further, iscoms induce APC to produce IL-1 , IL-6 and IL-12 and a TH1 type of response with enhanced IL-2 and IFN-gamma production