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MATK — PCNA

Text-mined interactions from Literome

Zhu et al., Mol Cell Biol 2004 (Genomic Instability) : We found that overreplication caused by depletion of geminin activated both Chk1 and Chk2 , which then phosphorylated Cdc25C on Ser216, resulting in its sequestration outside the nucleus, thus inhibiting cyclin B-Cdc2 activity
Kuo et al., Mol Cancer Ther 2009 (Breast Neoplasms) : In contrast, DHE caused S-G ( 2 ) /M arrest by increasing p21 expression and chk1 activation and inhibiting cyclin A, cyclin B, cdc25A, and cdc25C expression in MDA-MB-231 cells
Du et al., PloS one 2013 (Ovarian Neoplasms) : SB225002 induced mitotic catastrophe appeared to be mediated by down-regulation of checkpoint kinase Chk1 and Cdk1-cyclin B activation