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CYP2B6 — IRF6

Text-mined interactions from Literome

Li-Masters et al., Drug Metab Dispos 2001 : The effects of LPS on expression of phenobarbital ( PB ) -induced CYP2B1/2 in rats have been well characterized, but less is known about the effects of LPS on PB-induced CYP2B in mice ... Since genetically manipulated mice represent an attractive model to study the mechanisms involved in the down-regulation of CYP2B expression by LPS, we investigated the effects of LPS on PB-induced CYP2B expression in mouse liver ... LPS inhibited the mRNA expression of CYP2B10 and CYP2B9 at 6 and 12 h of treatment, with the inhibitory effect more profound at 12 h. LPS also suppressed the CYP2B9 mRNA level at 24 h
Khatsenko et al., Toxicol Lett 1997 : Here, we report that endogeneous nitric oxide also contributes to LPS induced suppression of CYP2B1/2 in vivo by down regulating the expression of CYP2B1/2 protein and mRNA
Mahéo et al., Hepatology 1998 : Moreover, it is shown that oltipraz induction of CYP1A2 and CYP2B1/2 and its suppression by E. coli LPS occurred at a transcriptional level