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SELE — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SELE → TNF (increases)
  Evidence: HUVECs were exposed to 2 ng/mLTNF-a for 5 hours or left untreated. This early time point was chosen to minimize indirect autocrine or paracrine effects. Efficacy of endothelial activation was controlled by flow cytometric analysis of E-selectin and ICAM-1 expression (Figure 1).
• OpenBEL Selventa BEL large corpus: SELE → TNF (increases, TNF Translocation)
  Evidence: Similar to freshly isolated HUVECs that respond to proinflammatory stimuli by the transcriptional upregulation of cell adhesion molecules, both AS-M.5 (not shown) and AS-M.5-Silco cells responded to stimulation by tumor necrosis factor-{alpha} (TNF-{alpha}) (100 ng/mL, 6 hours) and lipopolysaccharide (LPS; 1 µg/mL, 6 hours) by a transient induction of transcription of E-selectin and intercellular adhesion molecule-1 (ICAM-1) on the cell surface (Figure 4c).
• OpenBEL Selventa BEL large corpus: SELE → TNF (increases, TNF Translocation) Sorescu et al., J Biol Chem 2003*
  Evidence: Unlike ICAM-1, however, neither OS nor BMP4 had any effect on the surface expressions of VCAM-1 and E-selectin in endothelial cells, whereas TNF strongly increased both (Fig. 5, C and D).
• KEGG African trypanosomiasis: TNF → SELE (gene expression, expression)

Text-mined interactions from Literome

Eppihimer et al., Shock 1999 (Shock, Septic) : Role of tumor necrosis factor and interferon gamma in endotoxin induced E-selectin expression
Cockerill et al., Arterioscler Thromb Vasc Biol 1999 : E-selectin expression in response to tumor necrosis factor-alpha (TNFalpha) was, as expected, inhibited in ECs that had been preincubated with HDLs
Kalogeris et al., Am J Physiol 1999 : We found that TNF ( 10 ng/ml ) significantly enhanced U-937 and polymorphonuclear neutrophil ( PMN ) adhesion to HUVEC but not to ECV ; TNF also significantly enhanced surface expression of vascular cell adhesion molecule 1 and E-selectin ( in HUVEC only ), as well as intercellular adhesion molecule 1 ( ICAM-1 ; in HUVEC and ECV )
Kawata et al., Br J Pharmacol 1999 : 4. Antagonistic activity of E5531 was specific for lipopolysaccharide as it was ineffective at inhibiting interferon-gamma mediated NO release of RAW 264.7 cells, phorbor 12-myristate 13-acetate stimulated superoxide anion production in human neutrophils, concanavalin A stimulated mitogenic activity in murine thymocytes and tumor necrosis factor-alpha induced E-selectin expression in human umbilical vein endothelial cells
Chen et al., Free Radic Biol Med 1999 : Cells with marked depletion of cytoplasmic GSH, but with an intact pool of mitochondrial GSH, only slightly enhanced TNF-alpha induced E-selectin and vascular cell adhesion molecule-1 ( VCAM-1 ) expression, compared with the control
Iruela-Arispe et al., Microcirculation 1999 : Characterization of the isolated cultures included expression of endothelial cell markers, regulation of E-selectin in response to TNF-alpha , proliferative response to angiogenic growth factors, and expression of progesterone and estrogen receptors ... HEEC also upregulated E-selectin in response to TNF-alpha in a manner similar to that seen for other endothelial cell types
Langley et al., Am J Physiol 1999 (Neoplasms, Experimental...) : The dual radiolabeled monoclonal antibody technique was used to quantify constitutive and tumor necrosis factor (TNF)-alpha induced expression of intercellular adhesion molecule 1 ( ICAM-1 ), vascular cell adhesion molecule 1 ( VCAM-1 ), ICAM-2, P-selectin, E-selectin , and platelet-endothelial cell adhesion molecule 1 ( PECAM-1 ) in different vascular beds of normal ( C57Bl/6 ) and RM-1 tumor bearing mice
Trottein et al., Eur J Immunol 1999 : We found that lipophilic substance ( s ) present in the excretory/secretory products from schistosomula selectively reduce the TNF-alpha induced synthesis of E-selectin and VCAM-1 mRNA and proteins without affecting ICAM-1
Yao et al., Blood 1999 : We used in vitro and in vivo approaches to examine whether tumor necrosis factor-alpha (TNF-alpha) and oncostatin M (OSM), cytokines that bind to distinct classes of receptors, differentially regulate expression of P- and E-selectin in murine and primate endothelial cells
Gupta et al., Int J Immunopharmacol 1999 : We demonstrate here that out of three compounds, viz diferuloylmethane, p-coumaroylferuloylmethane and di-p-coumaroylmethane, present in the ethyl acetate extract of Curcuma longa, diferuloylmethane is most potent in inhibiting TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin on human umbilical vein endothelial cells
Ouchi et al., Circulation 1999 (Cardiovascular Diseases...) : Physiological concentrations of adiponectin dose-dependently inhibited TNF-alpha induced THP-1 adhesion and expression of VCAM-1, E-selectin , and ICAM-1 on HAECs
De Caterina et al., Am J Clin Nutr 2000 (Arteriosclerosis) : Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin , intercellular adhesion molecule 1 ( ICAM-1 ), interleukin 6 (IL-6), and IL-8 in response to IL-1, IL-4, tumor necrosis factor , or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Cominacini et al., Cell adhesion and communication 1999 : The addition of troglitazone to HUVECs significantly reduced the expression of ICAM-1, VCAM-1 and E-selectin induced by TNF-alpha alone or in combination with oxidized LDL ( p < 0.001 ) ; this reduction was paralleled by a significant fall in NF-kappaB translocation
Lidington et al., Transpl Immunol 1999 : Significant differences were found in the ability to respond to cytokines between HUVEC and the cell lines, the greatest differences being induction of VCAM-1 and E-selectin in response to TNF-alpha and induction of MHC class II antigens in response to IFN-gamma
Bandyopadhyay et al., J Immunol 2000 : Induction of E-selectin expression by double stranded RNA and TNF-alpha is attenuated in murine aortic endothelial cells derived from double stranded RNA activated kinase ( PKR ) -null mice ... Because we have previously shown that the dsRNA activated kinase PKR mediates dsRNA induction of NF-kappaB, we used murine aortic endothelial ( MuAE ) cells isolated from wild-type and PKR-null mice to investigate the role of PKR in the induction of E-selectin expression by dsRNA ( pIC ) and TNF-alpha ... These results indicate that the PKR is required for full activation of E-selectin expression by pIC and TNF-alpha in primary mouse aortic endothelial cells identifying activating transcription factor 2 as a new target for PKR dependent regulation and suggest a role for PKR in leukocyte adhesion
Brauer et al., Infect Immun 2000 (Pneumonia) : It has been shown that the membrane attack complex ( MAC ) ( C5b-C9 ) can enhance tumor necrosis factor alpha (TNF-alpha) induced expression of P- and E-selectin and intercellular adhesion molecule type 1 in cell cultures of human umbilical vein endothelial cells
Charreau et al., Transplantation 2000 : It is interesting that in vivo studies confirmed that CsA and GC inhibited EC activation at therapeutic doses ( 1 mg/kg and 10 mg/kg for GC and CsA, respectively ) and showed that the combination of CsA and GC efficiently prevents TNFalpha mediated induction of E-selectin on cardiac ECs
Kikuchi et al., Nihon Rinsho Meneki Gakkai Kaishi 2000 : The expression of ICAM-1 and E-selectin induced by TNF-alpha was not inhibited by either bFGF or VEGF
Woltmann et al., Blood 2000 : Tumor necrosis factor-alpha induced the expression of VCAM-1, E-selectin , and ICAM-1 but had no effect on P-selectin expression
Russell et al., Am J Physiol Gastrointest Liver Physiol 2000 (Ischemia) : These findings suggest that superoxide and TNF-alpha mediate gut I/R induced E-selectin expression via an NF-kappaB dependent mechanism ; this upregulation of E-selectin contributes significantly to I/R induced neutrophil recruitment
Harcourt et al., J Interferon Cytokine Res 2000 : Much higher levels of mRNA for interleukin-6 (IL-6), 2',5'-oligoadenylate synthetase ( 2',5'-OAS ), protein kinase ( PKR ), and interferon (IFN) regulatory factor-1 ( IRF-1 ) result from incubation with dsRNA than with IL-1beta, tumor necrosis factor-alpha (TNF-alpha), or IFN-alpha, whereas the differences in vascular cell adhesion molecule-1 ( VCAM-1 ), intercellular adhesion molecule-1 ( ICAM-1 ), and E-selectin mRNA expression in response to dsRNA, IL-1beta, and TNF-alpha are relatively minor
Stangl et al., Biochem Biophys Res Commun 2001 : Incubation of endothelial cells with homocysteine resulted in dose dependent reduction in TNF-alpha induced ( 5 ng/ml ) expression of VCAM-1, E-selectin , and ICAM-1 ( the latter less pronounced ) ... Since hyperhomocysteinemia appears to be an independent risk factor for the development of atherosclerosis, in this study we investigated the effect of homocysteine on basal and TNF-alpha induced expression of intercellular adhesion molecule-1 ( ICAM-1 ), vascular cell-adhesion molecule-1 ( VCAM-1 ), and endothelial leukocyte adhesion molecule-1 ( E-selectin ) on human umbilical-vein endothelial cells
Stewart et al., J Med Chem 2001 : A thieno [ 2,3-d ] pyrimidine, A-155918, was identified from a whole-cell high-throughput assay for compounds which inhibited the tumor necrosis factor-alpha (TNFalpha) induced expression of E-selectin , ICAM-1, or VCAM-1 on human vascular endothelial cells
Tremblay et al., Vet Pathol 2001 (Dermatitis...) : Control skin displayed no expression of E- and P-selectin, whereas TNF-alpha induced the expression of P-selectin and E-selectin on dermal vessels that was highest at 12 hours and 3 hours, respectively ( P < 0.05 ) ... These results demonstrate that TNF-alpha can induce the expression of P- and E-selectin in vivo in dog skin and suggest that these selectins are involved in leukocyte recruitment in canine dermatitis
Sharp et al., Inflammation 2001 (Inflammation) : At 4 h ICAM-1 and E-selectin , but not VACM-1, were stimulated by both IL-1beta and TNF-alpha ... Blocking PARP via GPI 6150 only affected TNF-alpha induced E-selectin expression at 4 hours ... ICAM-1, VCAM-1, and E-selectin expression were all stimulated by both IL-1beta and TNF-alpha in the 24 h assays
Asimakopoulos et al., J Thorac Cardiovasc Surg 2001 : Aprotinin inhibited tumor necrosis factor-alpha stimulated expression of intercellular adhesion molecule-1 ( P =.019 at 1600 kIU/mL ) and vascular cell adhesion molecule-1 ( P =.003 at 1600 kIU/mL ) but not E-selectin
Murakami et al., Microvasc Res 2001 : TNF-alpha induced the expression of E-selectin on all three kinds of endothelial cells, but IFN-gamma had no effect on E-selectin expression
Rasmussen et al., Biochem J 2001 : In contrast, TNF-alpha induced E-selectin protein expression was augmented after mevastatin treatment ... Analysis of the time dependent variation in the TNF-alpha induced expression of E-selectin , and estimation of the rate of surface disappearance of E-selectin together with measurement of the amounts of E-selectin molecules secreted, indicated that mevastatin inhibited the surface removal of E-selectin
Bahra et al., Cell Biochem Funct 2001 : Surface ELISA indicated that PTX reduced TNF induced upregulation of E-selectin
Loewe et al., J Invest Dermatol 2001 (Psoriasis) : Dimethylfumarate inhibits tumor-necrosis-factor induced CD62E expression in an NF-kappa B-dependent manner ... Using human umbilical vein endothelial cells, dimethylfumarate almost completely inhibited tumor-necrosis-factor induced CD62E , but not CD54 expression at concentrations < or = 70 microM, mimicking the situation in vivo ... A 60 min dimethylfumarate preincubation was sufficient to block tumor-necrosis-factor induced CD62E expression for up to 24 h ... In contrast, equimolar concentrations of methylhydrogenfumarate, the hydrolysis product of dimethylfumarate, did not suppress tumor-necrosis-factor induced CD62E expression ... Using CD62E, NF-kappa B, or AP-1-responsive promoter constructs, dimethylfumarate inhibited tumor-necrosis-factor induced activation of the CD62E and the NF-kappa B but not the AP-1 promoter construct
Zhang et al., Atherosclerosis 2002 : Inhibition of TNF-alpha induced ICAM-1, VCAM-1 and E-selectin expression by selenium
Watts et al., Anticancer Res 2002 (Adenocarcinoma...) : E-selectin ( peak at 4 hours ) and VCAM-1 ( peak at 24 hours ) expression were significantly increased by TNFalpha but unchanged by reduced oxygenation
Zhang et al., Life Sci 2002 : Effects of testosterone and 17-beta-estradiol on TNF-alpha induced E-selectin and VCAM-1 expression in endothelial cells ... This study investigated the effects of testosterone and 17-beta-estradiol on tumor necrosis factor-alpha (TNF-alpha) induced endothelial expression of E-selectin and vascular cell adhesion molecule-1 ( VCAM-1 ) and the potential roles of hormone receptors involved in these actions ... As shown by Western blot analysis, co-administration with testosterone or 17-beta-estradiol increased the expression of E-selectin and VCAM-1 induced by TNF-alpha at 6 h and 3 h, respectively ... Flow cytometric analysis showed that preincubation with androgen receptor antagonist cyproterone and estrogen receptor antagonist tamoxifen completely abrogated the upregulating effects of testosterone and 17-beta-estradiol on TNF-alpha induced E-selectin and VCAM-1 expression, respectively
Brand et al., Inflamm Res 2002 (Dermatitis, Allergic Contact...) : This finding was supported by the inability of TTO to suppress TNFalpha induced E-selectin expression by human umbilical vein endothelial cells
Chen et al., Atherosclerosis 2002 (Calcium Signaling) : Increased intracellular calcium transients by calmodulin antagonists differentially modulate tumor necrosis factor-alpha induced E-selectin and ICAM-1 expression ... The increased [ Ca ( 2+ ) ] ( i ) acted as a second messenger to enhance tumor necrosis factor-alpha (TNF-alpha) induced E-selectin and suppress intercellular cell adhesion molecule ( ICAM-1 ) expression
Spiecker et al., Mol Pharmacol 2002 : Tumor necrosis factor-alpha (TNF-alpha) induced endothelial VCAM-1, ICAM-1, and E-selectin surface expression was inhibited dose dependently
Cominacini et al., Am J Hypertens 2002 : Although zofenoprilat significantly and dose dependently reduced the expression of vascular cell adhesion molecule-1 ( VCAM-1 ), intercellular cell adhesion molecule-1 ( ICAM-1 ), and E-selectin induced by ox-LDL ( P < .01 ) and TNF-alpha ( P < .01 ) on HUVECs, enalaprilat did not
Omori et al., Free radical research 2002 : Monochloramine inhibits the expression of E-selectin and intercellular adhesion molecule-1 induced by TNF-alpha through the suppression of NF-kappaB activation in human endothelial cells ... We studied the effects of monochloramine ( NH2Cl ), a physiological oxidant derived from activated neutrophils, on the TNF-alpha induced expression of E-selectin and intercellular adhesion molecule-1 ( ICAM-1 ) in human umbilical vein endothelial cells ( HUVEC ) ... These observations indicated that NH2Cl inhibited TNF-alpha induced expression of E-selectin and ICAM-1 through the inhibition of NF-kappaB activation
Landis et al., Arthritis Rheum 2002 : Human peripheral blood monocytes were differentiated for 1-7 days in vitro and examined with respect to 1 ) uptake of MSU crystals, 2 ) expression of macrophage, dendritic cell, and activation markers, 3 ) secretion of tumor necrosis factor alpha (TNFalpha) , interleukin 1beta (IL-1beta), IL-6, and IL-10, 4 ) activation of endothelial E-selectin expression, and 5 ) enhancement of secondary neutrophil recruitment by endothelial cells ... MSU crystals induced TNFalpha , IL-1beta, and IL-6 ( but not IL-10 ) secretion in undifferentiated monocytes, which in turn promoted endothelial cell E-selectin expression and secondary neutrophil capture under shear flow
Chen et al., Circulation 2002 : Stimulation of the Ad.null infected endothelial cells with TNF-alpha resulted in enhanced expression of endothelial intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, and E-selectin and enhanced adhesion of monocytic U937 cells to the HAECs
Scholzen et al., Endocrinology 2003 (Vasculitis) : In HDMEC, alpha-MSH ( 10 ( -8 ) /10 ( -12 ) M ) profoundly reduced the mRNA and protein expression of E-selectin , vascular CAM (VCAM)-1, and intercellular CAM (ICAM)-1 induced by LPS or TNFalpha as determined by semiquantitative RT-PCR, ELISA, and fluorescence activated cell sorter analysis
Kraiss et al., J Vasc Surg 2003 : Fluid flow inhibited E-selectin protein levels by about 50 % in response to TNF-alpha but had no effect on total E-selectin messenger RNA ( mRNA ) expression
Bouhlal et al., J Fr Ophtalmol 2002 : On TNFalpha activated HUVECs, NAAGA induced a significant decrease in the VCAM-1 expression level ( P < 0.0001 ) and totally reversed TNFalpha induced overexpression of ICAM-1 ( P=0.0069 ), ICAM-2 and ELAM-1 ( P < 0.0001 ), without interfering with baseline expression of these molecules
O'Reilly et al., J Invest Dermatol 2003 : MG132 only partially blocked tumor necrosis factor-alpha induced tissue factor protein expression, despite an almost complete inhibition of tumor necrosis factor-alpha induced E-selectin expression
Chen et al., J Pharmacol Exp Ther 2003 : In the present study, we demonstrate that adenoviral mediated expression of dominant negative N17Rac1 ( Ad.N17Rac1 ) suppresses tumor necrosis factor-alpha (TNF-alpha) induced vascular cell adhesion molecule-1 ( VCAM-1 ), intercellular adhesion molecule-1 ( ICAM-1 ), and E-selectin gene expression in a dose dependent manner ... In contrast, Ad.N17Rac1 inhibited TNF-alpha induced NF-kappaB-driven HIV ( kappaB ) ( 4 ) -CAT and p288VCAM-Luc promoter activity, suggesting that N17Rac1 inhibits TNF-alpha induced VCAM-1, E-selectin , and ICAM-1 through suppressing NF-kappaB mediated transactivation ... In addition, expression of superoxide dismutase by adenovirus suppressed TNF-alpha induced VCAM-1, E-selectin , and ICAM-1 mRNA accumulation ... However, adenoviral mediated expression of catalase only partially inhibited TNF-alpha induced E-selectin gene expression and had no effect on VCAM-1 and ICAM-1 gene expression
Zhang et al., Free Radic Biol Med 2003 : Treatment of HAEC with DFO ( 0.01-0.1 mM ) or NC ( 0.1 and 0.5 mM ) time- and dose-dependently inhibited TNFalpha induced protein expression of E-selectin , vascular cell adhesion molecule-1 ( VCAM-1 ), and intercellular adhesion molecule-1 ( ICAM-1 )
Uchiba et al., Crit Care Med 2003 : Gabexate mesilate inhibited the tumor necrosis factor-alpha induced increases in the endothelial expression of E-selectin and intercellular adhesion molecule-1 by inhibiting the transcription
Dagia et al., Am J Physiol Cell Physiol 2003 : We show, for the first time, that lactacystin inhibits 1 ) 4-h concurrent IL-1 beta- and TNF-alpha induced expression of E-selectin , VCAM-1, ICAM-1, and HL60 cell adhesion to HUVEC ; 2 ) 4-h TNF-alpha induced expression of E-selectin, VCAM-1, and HL60 cell adhesion to HUVEC that have become desensitized to IL-1 beta activation ; 3 ) 24-h TNF-alpha induced expression of E-selectin and VCAM-1 but not ICAM-1 ; and 4 ) 24-h TNF-alpha induced HL60 cell adhesion to HUVEC
Engelberts et al., J Surg Res 1992 : To establish an optimal effect for both TNF alpha induced cytotoxicity on L929 cells and TNF alpha induced expression of ELAM-1 on human endothelial cells, the TNF receptor had to be occupied by TNF alpha for at least 30-60 % of the full incubation period ... We therefore studied the relation between the duration of TNF alpha/TNF receptor interaction and the extent of the induced biological effects in two different in vitro systems : ( 1 ) the slowly induced cytotoxicity of the TNF-sensitive murine cell line L929, and ( 2 ) the rapid TNF alpha induced expression of an adhesion molecule for the polymorphonuclear cell, ELAM-1 on human endothelial cells
Koizumi et al., Biol Pharm Bull 2003 : DMSO did not affect expression of E-selectin on endothelial cells in the presence of TNF-alpha
Nofer et al., Biochem Biophys Res Commun 2003 : We here investigated the effects of sphingosylphosphorylcholine (SPC) and lysosulfatide ( LSF ), two lysosphingolipids associated with HDL, on TNF-alpha induced E-selectin expression in human umbilical endothelial cells ... The inhibitory effects of HDL, SPC, and LSF on TNF-alpha induced E-selectin expression were partially reverted in the presence of suramin, an antagonist of lysosphingolipid receptor EDG-3, or pertussis toxin, an inhibitor of trimeric G proteins
Dvorin et al., J Heart Valve Dis 2003 : HPVEC express E-selectin , ICAM-1, and VCAM-1 in response to the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) similarly to other types of cultured human endothelial cells
Sakurai et al., J Cell Physiol 2004 : The catalytic Sec residue of TrxR1, which is essential for reducing Trx, was required for this NF-kappa B activation, and aurothiomalate, an inhibitor of TrxR, suppressed TNF alpha induced activation of NF-kappa B and the expression of NF-kappa B-targeted proinflammatory genes such as E-selectin and cyclooxygenase-2
Chiu et al., Arterioscler Thromb Vasc Biol 2004 : Shear stress increases ICAM-1 and decreases VCAM-1 and E-selectin expressions induced by tumor necrosis factor- [ alpha ] in endothelial cells ... Shear stress increased the TNF-alpha induced expression of intercellular adhesion molecule-1 ( ICAM-1 ) at both mRNA and surface protein levels, but decreased the TNF-alpha induced expression of vascular adhesion molecule-1 (VCAM-1) and E-selectin ... Our findings suggest that shear stress plays differential roles in modulating the TNF-alpha induced expressions of ICAM-1 versus VCAM-1 and E-selectin genes in ECs
Dimitrova et al., Journal of thrombosis and haemostasis : JTH 2003 : Furthermore, GGTI-286, but not FTI-277, mimicked the effect of simvastatin by increasing the TNF-alpha mediated overexpression of E-selectin
Nübel et al., FASEB J 2004 (Neoplasms) : Lovastatin mediated block of TNF-alpha induced E-selectin expression is due to inhibition of protein geranylgeranylation rather than farnesylation
Takano-Ishikawa et al., Phytother Res 2003 : The present study investigates the suppressive effect of flavonoids on TNF-alpha stimulated E-selectin expression on HUVECs by carrying out a comparative examination of the 37 flavonoids
Furbert-Harris et al., Cell Mol Biol Incl Cyto Enzymol 2003 (Neoplasm Metastasis...) : TNF-alpha and IL-10 enhanced ELAM-1 on DU 145, but EosA 24 hr supematants failed to do so ... All three cytokines, namely IL-10, IL-12 and TNF-alpha induced ELAM-1 on PC-3 tumor cells
Chua et al., Cell Mol Biol Incl Cyto Enzymol 2003 (Mucocutaneous Lymph Node Syndrome) : Using semi-quantitative RT-PCR and cell based ELISA, we demonstrated that tumor necrosis factor-a induced the expression of intercellular adhesion molecules-1 and E-selectin , as well as monocyte chemoattractant protein-1, in a time- and dose dependent manner in primary human coronary artery endothelial cell cultures
Makondo et al., Biochim Biophys Acta 2004 : Hepatocyte growth factor/scatter factor suppresses TNF-alpha induced E-selectin expression in human umbilical vein endothelial cells ... Prior treatment of HUVEC with HGF significantly attenuated the tumor necrosis factor (TNF)-alpha induced E-selectin protein, adhesion of HL60 cells to HUVEC and E-selectin mRNA expression in a dose dependent manner, while HGF itself did not exert any effects
Sibson et al., Magn Reson Med 2004 (Encephalitis) : Both TNF-alpha and IL-1beta up-regulated E-selectin on the brain endothelium, which correlated with increased signal intensity observed after administration of the novel contrast agent
Hansen et al., J Clin Endocrinol Metab 2004 (Metabolism, Inborn Errors) : Furthermore, we studied the direct effect of GH and IGF-I and serum from GH-treated subjects on basal and TNF alpha stimulated expression of VCAM-1 and E-selectin on cultured human umbilical vein endothelial cells
Altannavch et al., Physiol Res 2004 (Arteriosclerosis...) : The effect of high glucose concentration on TNF-alpha induced expression of ELAM-1 , VCAM-1 and ICAM-1 was negligible, if at all
Dirsch et al., Eur J Nutr 2004 : The TNF-alpha induced expression of the endothelial adhesion molecule E-selectin was not reduced in response to DADS or AM
VandenBerg et al., J Cell Biochem 2004 : TNF-alpha increased VCAM-1, ICAM-1, and E-selectin by 4 h but had no affect on the expression of PECAM
Choi et al., J Nutr 2004 : TNF-alpha significantly induced HUVEC protein expression of VCAM-1, ICAM-1, and E-selectin with increasing mRNA levels
Ichiyama et al., Inflamm Res 2004 : Moreover, the inhibitory effects of IVIG on IkappaBalpha degradation, interleukin-6 (IL-6) production, and E-selectin expression induced by TNF-alpha were evaluated by Western blot analysis, ELISA, and flow cytometry, respectively ... Moreover, IVIG inhibited IkappaBalpha degradation, IL-6 production, and E-selectin expression induced by TNF-alpha in CAEC
Jiang et al., Life Sci 2004 : The mRNA expression of E-selectin , ICAM-1 and VCAM-1, and activation of NF-kappaB induced by TNF-alpha for 2 h were significantly decreased by the above two pretreatments
Wadgaonkar et al., Am J Respir Cell Mol Biol 2004 : The rapid and transient induction of E-selectin gene expression by inflammatory tumor necrosis factor (TNF)-alpha in endothelial cells is mediated by signaling pathways which involve c-Jun N-terminal kinase (JNK) and p38 mitogen activated protein kinase ( MAPK ) kinase pathways
Dagia et al., J Immunol 2004 : We found that compound 10 1 ) dramatically inhibits TNF-alpha induced VCAM-1 mRNA and protein expression in human aortic endothelial cells ( HAEC ), has a relatively modest inhibitory effect on TNF-alpha induced E-selectin expression and has no effect on ICAM-1 expression ; 2 ) significantly reduces TNF-alpha induced monocytic ( U937 ) cell adhesion to HAEC under in vitro flow conditions similar to that present in vivo ; 3 ) inhibits TNF-alpha induced IFN regulatory factor-1 binding to VCAM-1 promoter ; and 4 ) reduces TNF-alpha induced IRF-1 expression in HAEC
Chen et al., Arterioscler Thromb Vasc Biol 2004 : Compared with control condition, pretreatment of carvedilol ( 10 micromol/L for 18 hours ) or probucol ( 5 micromol/L for 18 hours ), but not propanolol, prazosin, or both propanolol and prazosin significantly decreased TNF-alpha stimulated adhesiveness of cultured human aortic endothelial cells ( HAECs ) to MNCs. Carvedilol inhibited TNF-alpha stimulated endothelial vascular cell adhesion molecule-1 ( VCAM-1 ) and E-selectin ( 66.0+/-2.0 % and 55.60+/-1.0 % of control, P < 0.05, respectively ) expression, whereas probucol inhibited only VCAM-1 expression ( 79.0+/-5.0 % of control, P < 0.05 )
Costa et al., Xenotransplantation 2004 : We first evaluated by flow cytometry the pTNFR1Ig capacity to prevent TNF alpha induced expression of SLAI, SLAII, VCAM-1, ICAM-1 and E-selectin on the cell surface of porcine aortic endothelial cells ( PAEC )
Uchiba et al., Thromb Haemost 2004 : These observations suggested that AT inhibited the TNF-alpha induced increase in E-selectin expression in HUVECs by inhibiting the interaction of NF-kappaB with CBP/p300 through cAMP dependent protein kinase A-induced CREB activation
Enis et al., Proc Natl Acad Sci U S A 2005 (Ischemia) : As in skin, TNF induces E-selectin and vascular cell adhesion molecule 1 only on venular ECs, whereas intercellular adhesion molecule-1 is up-regulated on all human ECs
Harada et al., Nephron. Experimental nephrology 2005 : In these cells, ICAM-1 and E-selectin expression was up-regulated by TNF-alpha , as in native cultured HGEC
Stangl et al., J Nutr 2005 : Phloretin prevented TNF-alpha stimulated upregulation of VCAM-1, ICAM-1, and E-selectin expression in a concentration dependent manner
Sasaki et al., BMC physiology 2005 : Trogliazone ( 20 microM ) reduced TNF-alpha induced VCAM-1, ICAM-1 and E-selectin expression
Kwon et al., Arch Pharm Res 2005 : Also, 1 and 2 inhibited TNF-alpha induced up-regulation of ICAM-1, VCAM-1 and E-selectin
Jiang et al., Respir Med 2005 : The mRNA expression of E-selectin , ICAM-1 and VCAM-1, and activation of NF-kappaB induced by TNF-alpha for 2 h were decreased significantly by the above two pretreatments
Nascimento-Silva et al., Am J Physiol Cell Physiol 2005 (Acute-Phase Reaction) : We demonstrate that treatment of EC with ATL-1 inhibited VCAM and E-selectin expression induced by TNF-alpha or IL-1beta
Wang et al., Br J Pharmacol 2005 : TNF-alpha increased E-selectin mRNA expression in both wild-type ( WT ) and mast cell-deficient mice
Kwon et al., J Agric Food Chem 2005 : In contrast, hydroxyflavone minimally inhibited TNF-alpha stimulated E-selectin expression without affecting VCAM-1 level
Khatib et al., Am J Pathol 2005 (Carcinoma, Lewis Lung...) : Furthermore, the rapidly induced production of TNF-alpha was followed by increased expression of the vascular adhesion receptors E-selectin P-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 on sinusoidal endothelial cells
Chen et al., Mol Cell Biol 2005 : Reconstitution of RelA-deficient murine embryonic fibroblasts with RelA S276A or RelA S536A decreased TNF-alpha induced acetylation of lysine 310 and expression of the endogenous NF-kappaB-responsive E-selectin gene
De Bosscher et al., Proc Natl Acad Sci U S A 2005 (Inflammation) : We demonstrate that CpdA exerts an antiinflammatory potential by down modulating TNF induced proinflammatory gene expression, such as IL-6 and E-selectin , but, interestingly, does not at all enhance glucocorticoid response element-driven genes or induce GR binding to glucocorticoid response element dependent genes in vivo
Lieder et al., Anticancer Res 2005 (Carcinoma, Squamous Cell...) : These findings support the hypothesis that expression of E-selectin and VCAM-1 may be initiated by the release of tumour necrosis factor-alpha (TNF-alpha) at an early stage of tumour development
Kurata et al., World J Gastroenterol 2006 (Colonic Neoplasms...) : To examine whether antithrombin ( AT ) could prevent hepatic ischemia/reperfusion ( I/R ) -induced hepatic metastasis by inhibiting tumor necrosis factor (TNF)-alpha induced expression of E-selectin in rats ... AT might reduce I/R induced hepatic metastasis of colon cancer cells by inhibiting TNF-alpha induced expression of E-selectin through an increase in the endothelial production of PGI2
Schmidt et al., Basic Res Cardiol 2006 (Atherosclerosis...) : In previous studies we have shown that high density lipoproteins ( HDL ) and the HDL associated sphingosylphosphorylcholine (SPC) have the ability to suppress the TNF-alpha induced expression of endothelial cell E-selectin
Gong et al., Kidney Int 2006 (Acute Disease...) : In vitro, HGF suppressed TNF-alpha induced cell surface expression of E-selectin in human umbilical vein endothelial cells ( HUVEC ) and inhibited E-selectin mediated monocytic adhesion to endothelial monolayers ... In addition, selective inhibition of GSK3 activity by lithium suppressed TNF-alpha induced E-selectin expression and monocytic adhesion, reminiscent of the action of HGF
Ogawara et al., Arthritis Res Ther 2006 : RGD targeted adenovirus delivered the dnIkappaB via alphavbeta3 to become functionally expressed, leading to complete abolishment of TNF-alpha induced up-regulation of E-selectin , ICAM-1, VCAM-1, IL-6, IL-8, VEGF-A and Tie-2
Mo et al., J Ethnopharmacol 2007 : Evidence presented in this report demonstrated that CML-1 inhibited the adhesive capacity of HUVEC and the TNF-alpha mediated induction of E-selectin , ICAM-1 and VCAM-1 in HUVEC by inhibiting the IkB/NF-kB signaling pathway at the level of IkB kinase, which may explain the ability of CML-1 to suppress inflammation and modulate the immune response
Thornhill et al., J Immunol 1990 : Furthermore, IL-4 exhibited significant synergy with IL-1 or TNF in inducing 1.4C3 Ag expression ( p less than 0.001 ) but inhibited the increased expression of ICAM-1 produced by IL-1, TNF, or IFN-gamma ( p less than 0.01 ) and inhibited the induction of ELAM-1 by IL-1 and TNF ( p less than 0.001 )
Doukas et al., J Immunol 1990 : IFN-gamma increases TNF induced ELAM-1 expression such that a greater number of EC express ELAM-1 at both 4 and 24 h in the presence of IFN-gamma plus TNF compared to cultures treated with TNF alone, although the maximal level of surface expression on individual cells is not increased
Leeuwenberg et al., J Immunol 1990 : ELAM-1 is normally not expressed by HUVE cells, but its expression can rapidly be induced by TNF , IL-1, or LPS
Chandrasekharan et al., Blood 2007 : We observed that p75 was essential for TNF-alpha induced E-selectin , vascular cell adhesion molecule 1 ( VCAM-1 ), and intercellular adhesion molecule 1 ( ICAM-1 ) expression
Stannard et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : In contrast, pretreatment of human umbilical vein endothelial cells with VEGF significantly increased E-selectin expression induced by tumor necrosis factor-alpha , compared with tumor necrosis factor-alpha alone, whereas vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 were unaffected
Methe et al., Am J Physiol Heart Circ Physiol 2007 (Mechanotransduction, Cellular) : Venous and coronary artery flow both increased TNF-alpha induced E-selectin and ICAM-1 expression on HSVEC, but only coronary artery flow increased VCAM-1 expression ... In marked contrast to HSVEC, venous and coronary artery flow attenuated TNF-alpha induced E-selectin and VCAM-1 expression on HCAEC, whereas coronary artery flow further induced ICAM-1 on cytokine stimulated HCAEC ... Interestingly, Kruppel-like factor (KLF) 4 overexpression in HCAEC and HSVEC significantly reduced TNF-alpha induced E-selectin and VCAM-1 expression in static conditions, while ICAM-1 expression remained constant
Leeuwenberg et al., Eur J Immunol 1991 (Leukemia, Myeloid) : ELAM-1 expression can selectively be induced on human umbilical vein endothelial cells ( HUVEC ) by tumor necrosis factor , interleukin 1 and lipopolysaccharide
Harrington et al., Lung 2006 : Tumor necrosis factor-alpha (TNFalpha) significantly increased EC E-selectin surface expression ... These results indicate that TNFalpha activation, but not apoptosis, is necessary for E-selectin surface expression in EC
Kwon et al., Experimental biology and medicine (Maywood, N.J.) 2007 : Isoliquiritigenin abolished TNF-alpha induced mRNA accumulation of VCAM-1 and E-selectin
Kumar et al., Bioorg Med Chem 2007 : We have found that compound 8a also significantly inhibited the TNF-alpha induced expression of VCAM-1 and E-selectin , which play key roles in various inflammatory diseases
Bandyopadhyay et al., Mol Cell Biol 2007 : The depletion of HOXA9 protein in ECs resulted in a significant and specific decrease in tumor necrosis factor alpha (TNF-alpha) induced E-selectin gene expression ... We have thus identified a novel and functionally critical cis-regulatory element for TNF-alpha mediated transient expression of the E-selectin gene
Sanz et al., Br J Pharmacol 2007 : In vitro, the effects of roflumilast N-oxide, the active metabolite of roflumilast in humans, and other PDE4 inhibitors on neutrophil adhesion to tumour necrosis factor alpha (TNFalpha) activated human umbilical vein endothelial cells ( HUVEC ), E-selectin expression and thrombin induced endothelial permeability was evaluated ... It also reduced TNFalpha induced E-selectin expression on HUVEC, when PDE3 activity was blocked
Mangan et al., Cardiovasc Res 2007 : OPG but not OPN stimulated a dose dependent increase in the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin by endothelial cells in the presence of TNF-alpha ( p < or=0.05 ) which was reflected by enhanced binding of THP-1 monocytes
Ohno et al., Oncol Res 2005 : It also inhibited TNF-alpha induced expression of intercellular adhesion molecule-1 ( ICAM-1 ), vascular cell adhesion molecule-1 ( VCAM-1 ), and E-selectin
Seldon et al., J Immunol 2007 (Inflammation) : Basal and TNF induced expression of VCAM-1, ICAM-1, and E-selectin were increased in Hmox1 ( -/- ) vs Hmox1 ( +/+ ) EC, an effect reversed by Fe chelation using deferoxamine mesylate ( DFO )
Lee et al., Arch Pharm Res 2007 : Apigenin significantly suppressed the TNF-alpha stimulated upregulation of vascular cellular adhesion molecule-1 ( VCAM-1 ) -, intracellular adhesion molecule-1 ( ICAM-1 ) -, and E-selectin-mRNA to the basal levels
Fan et al., Arterioscler Thromb Vasc Biol 2008 (Inflammation) : In human umbilical vein endothelial cells ( HUVECs ), the synthetic PPAR-delta ligands GW0742 and GW501516 significantly inhibited tumor necrosis factor (TNF)-alpha induced expression of vascular cell adhesion molecule-1 and E-selectin ( assayed by real-time RT-PCR and Northern blotting ), as well as the ensuing endothelial-leukocyte adhesion
Lin et al., Arterioscler Thromb Vasc Biol 2008 (Inflammation) : FIR radiation also inhibited tumor necrosis factor (TNF)-alpha mediated expression of E-selectin , vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, monocyte chemoattractant protein-1, interleukin-8, and the cytokine mediated adhesion of monocytes to ECs
Liu et al., Am J Pathol 2008 : In organ culture, TNF induced expression of E-selectin , VCAM-1, and ICAM-1 on HUVECs but only ICAM-1 on HUAECs ... Transduction of HUVECs with KLF2 reduced TNF mediated induction of E-selectin and VCAM-1 while increasing ICAM-1 induction and reduced transcription factor/co-activator binding to the E-selectin enhancer
Yoshizaki et al., Biochem Biophys Res Commun 2008 (Inflammation) : Transfection in human aorta endothelial cells ( HAECs ) with these constructs revealed that the E-selectin promoter was sufficiently activated in response to tumor necrosis factor-alpha (TNF-alpha) , and miR-E1 and miR-E2 could suppress E-selectin expression resulting in the significant inhibition of leukocyte adhesion
Warfel et al., J Immunol 2008 : LT failed to augment TNF induced ICAM-1 or E-selectin expression, two adhesion molecules regulated by NF-kappaB, but not IRF-1
Zhang et al., Acta Pharmacol Sin 2008 : The TNF-alpha- induced expressions of P-selectin and E-selectin on the surface of BMECs were determined by Western blotting
Rajan et al., J Cell Biochem 2008 : We further demonstrated that inhibition of NF-kappaB completely blocked TNF-alpha induced expression of ICAM-1, VCAM-1 and E-selectin ... The inhibition of SB at 10 microM on TNF-alpha induced ICAM-1, VCAM-1 and E-selectin is likely due to the nonspecific effect of SB
Ringseis et al., Regul Pept 2009 : Treatment of human aortic endothelial cells ( HAEC ) with 50 microM of Val-Pro-Leu, Ser-Ser-Ser and Glu-Glu-Glu inhibited TNFalpha induced monocyte adhesion and expression of the adhesion molecule E-selectin ( P < 0.05 )
Wang et al., J Perinatol 2009 (Pre-Eclampsia) : ( 1 ) TNFalpha induced dose dependent increases in ICAM, VCAM and E-selectin expressions in endothelial cells ; ( 2 ) Digibind could attenuate and reduce TNFalpha induced upregulation of endothelial E-selectin , ICAM and VCAM expressions
Limaye et al., Cell Mol Biol Lett 2009 (Arthritis, Rheumatoid...) : The cells showed constitutive activation as evidenced by the induction of basal VCAM-1 expression, and further showed a more augmented VCAM-1 and E selectin response to TNF compared with empty vector control cells ( EC ( EV ) ) ... By contrast, over-expression of a dominant negative SK inhibited the TNF induced VCAM-1 and E selectin and inhibited PMN adhesion, confirming that the observed effects were specifically mediated by SK
Ming et al., BMC cardiovascular disorders 2009 : The induction of the expression of endothelial VCAM-1, ICAM-1 and E-selectin by TNFalpha was concentration-dependently reduced by incubation of the endothelial cells with the arginase inhibitor L-norvaline
Piqueras et al., J Leukoc Biol 2009 (Inflammation) : These inhibitory responses of GW501516 on activated endothelium were accompanied by a reduction in TNF-alpha induced endothelial GRO-alpha release and VCAM-1, E-selectin , and ICAM-1 mRNA expression
Summer et al., Am J Physiol Lung Cell Mol Physiol 2009 (Disease Models, Animal...) : We found that APN localizes to the luminal side of blood vessels in lung and acts in vitro to block TNF-alpha induced E-selectin upregulation in pulmonary artery endothelial cells
Madlener et al., Int J Oncol 2009 (Breast Neoplasms...) : We demonstrate here that extracts of A. alopecuroidea can inhibit TNFalpha induced E-selectin production, providing a mechanistic validation of its traditional use against inflammatory diseases
Zanni et al., Clin Endocrinol (Oxf) 2010 (Metabolic Syndrome X...) : The objectives of this study were to : ( 1 ) determine the body composition, metabolic and inflammatory factors associated with increased E-selectin and ( 2 ) determine the role of TNF-alpha in the physiological regulation of E-selectin by antagonism of TNF-alpha with etanercept among obese subjects ... TNF-alpha antagonism with etanercept reduces E-selectin in obese subjects, providing evidence that the systemic circulatory release of E-selectin is regulated at least in part by TNF-alpha in obesity
Braham et al., J Periodontol 2009 : A cytokine inactivation assay that measured E-selectin expression in response to TNF-alpha and IL-1 beta was developed to measure the ability of aPDT to inactivate cytokine function
Hu et al., Pharmacology 2010 : The protein and mRNA levels of tumor-necrosis-factor-alpha (TNF-alpha) induced ICAM-1, VCAM-1 and E-selectin were determined in HUVECs ... These data suggested that the effect of puerarin mediated inhibition of TNF-alpha induced ICAM-1, VCAM-1 and E-selectin expression is attributed to suppressed NF-kappaB activation on the transcriptional level
Grünewald et al., Journal of inflammation (London, England) 2010 : This correlates with increased translocation of the transcription factor NF-kB to the nucleus, which is known to regulate ICAM-1, VCAM-1 and E-selectin expression in response to TNF-alpha
Zhou et al., J Pharmacol Exp Ther 2010 : Real-time reverse transcription-polymerase chain reaction data demonstrated a significant inhibition of tumor necrosis factor (TNF)alpha induced E-selectin mRNA levels after ES936 pretreatment ... Immunoblot assays demonstrated a significant reduction in TNFalpha stimulated E-selectin , VCAM-1, and ICAM-1 proteins after inhibition or knockdown of NQO1
Cheng et al., J Immunol 2010 : This increase was independent of alterations in TNF induced expression of E-selectin , VCAM-1, and ICAM-1
Gupta et al., Biochimie 2010 : beta-sitosterol also significantly inhibited the TNFalpha induced expression of VCAM-1 and E-selectin , which also play key role in various inflammatory diseases
Hattori et al., Diabetologia 2010 : It also reduced TNFalpha induced MCP-1 ( also known as CCL2 ), VCAM1, ICAM1 and E-selectin mRNA expression
Takeda et al., Bioorg Med Chem Lett 2010 : As a result, 7-O-cinnamoylmorroniside was observed to be a potent inhibitor of TNF-alpha induced E-selectin expression
Makó et al., Cytometry A 2010 : Moreover, expression of E-selectin , IL-6, and IL-8 was induced most efficiently by IL-1ß, while LPS and TNF-a had less effect, whereas we did not find such a difference in ICAM-1 and MCP-1 expression
St Hill et al., Cancer 2011 (Carcinoma, Non-Small-Cell Lung...) : Stimulation of FucT-III transfected cells with recombinant human ( rh ) TNF-a up-regulated sLeX expression and increased E-selectin binding
Lin et al., J Sci Food Agric 2011 : Immunoblot analysis showed that Monascus fermented rice metabolites significantly attenuated TNF-a induced VCAM-1 and E-selectin but not ICAM-1 protein expression ... Monascus fermented rice metabolites reduced TNF-a stimulated endothelial adhesiveness as well as downregulating intracellular ROS formation, NF-?B activation, and VCAM-1/E-selectin expression in HAECs, supporting the notion that the various metabolites from Monascus fermented rice might have potential implications in clinical atherosclerosis disease
Chen et al., Vascul Pharmacol 2011 : ZLJ-6, a novel COX/5-LOX inhibitor, attenuates TNF-a induced endothelial E-selectin , ICAM-1 and VCAM-1 expression and monocyte-endothelial interactions via a COX/5-LOX independent mechanism
Sölder et al., Microvasc Res 2012 : Various functional tests ( Dil-Ac-LDL uptake, Matrigel assay and TNF-a induced upregulation of CD62E and CD54 ) substantiated the endothelial nature of propagated fEC
Roth Flach et al., J Biol Chem 2013 (Diabetes Mellitus, Type 2...) : Increased expression of adipose tissue cytokines IL-1ß, CCL2, and TNF-a in response to CL 316,243 administration is also dependent upon E-selectin but not P-selectin
Chen et al., Exp Dermatol 2013 : Furthermore, PF markedly blocked tumor necrosis factor-a (TNF-a) induced E-selectin and intercellular adhesion molecule-1 ( ICAM-1 ) expression in HDMECs at both mRNA and protein levels
Tanigawa et al., Immunopharmacol Immunotoxicol 2013 : Among 11 flavones, acacetin strongly inhibited TNF-a induced E-selectin expression in HUVECs
Yang et al., J Immunol 1994 (Sarcoma, Kaposi...) : ICAM-1, VCAM-1, and E-selectin were all induced by dsRNA ( poly ( I:C ) ), IL-1 beta, TNF-alpha , and LPS in KS cells
Slowik et al., Am J Pathol 1993 : In contrast, ELAM-1 induction by R32W-TNF is only inhibited by anti-p55
Read et al., J Exp Med 1994 : I kappa B-alpha inhibits p65 or TNF-alpha stimulated E-selectin promoter-reporter gene expression in transfected endothelial cells
Cockerill et al., Lab Invest 1994 (Trisomy) : We also examined the tumor necrosis factor (TNF) mediated upregulation of E-selectin , vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 ... CD34 expression of this cell line and the ability of transforming growth factor-beta to inhibit the TNF-alpha induction of E-selectin was examined ... The ability of interleukin-4 to enhance the expression of VCAM and reduce the TNF-alpha mediated expression of E-selectin is maintained in this cell line
Woolley et al., Immunology 1995 (Inflammation) : Immunocytochemistry of frozen sections from sponges showed that E-selectin expression was up-regulated markedly by TNF-alpha and PHA at 5 hr, only moderately by IL-1 alpha at 5 hr, and not at all by PMA at 5 hr
Weber et al., Circulation 1995 : The induction of vascular cell adhesion molecule-1 ( VCAM-1 ) and E-selectin by tumor necrosis factor-alpha (TNF) is mediated by mobilization of the transcription factor nuclear factor-kappa B (NF-kappa B)
Groves et al., Br J Dermatol 1995 (Dermatitis...) : TNF-alpha induced endothelial E-selectin , intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in all groups, and adhesion molecule expression by interstitial dermal dendritic cells ( ICAM-1 and VCAM-1 ) and keratinocytes ( ICAM-1 ) was observed
Altavilla et al., Am J Physiol 1995 (Arterial Occlusive Diseases...) : Tumor necrosis factor induces E-selectin production in splanchnic artery occlusion shock
Weber et al., J Immunol 1995 : Induction of VCAM-1 and ELAM-1 surface expression by TNF was dose-dependently reduced by pretreatment with the protein tyrosine kinase inhibitors herbimycin A ( HMA, IC50 300 nM ) or genistein ( IC50 30 microM ) ... Our data suggest that specific phosphorylation following protein tyrosine kinase activation may be required for NF-kappa B mobilization and induction of VCAM-1 and ELAM-1 by TNF
Kilgore et al., J Immunol 1995 : Enhancement by the complement membrane attack complex of tumor necrosis factor-alpha induced endothelial cell expression of E-selectin and ICAM-1 ... This conclusion was further supported by a whole-cell ELISA, which provided evidence that the MAC augments TNF-alpha induced up-regulation of both E-selectin and ICAM-1
Ferran et al., Biochem Biophys Res Commun 1995 : We show that pyrrolidine dithiocarbamate strongly reduces the TNF alpha mediated induction of E-selectin , VCAM-1, ICAM-1, PAI-1, tissue factor, IL-8 and I kappa B-alpha
Leeuwenberg et al., Cytokine 1995 : The current study was undertaken to investigate the role of TNF-R75 in regulation of E-selectin and ICAM-1 expression by TNF on HUVEC ... In contrast, both MR2-1 and pAb75 inhibited specifically TNF induced E-selectin and ICAM-1 expression, but not activation by IL-1 or LPS
Pober et al., J Immunol 1993 : Unexpectedly, this combination of cAMP elevating drugs inhibits TNF induction of ELAM-1 and VCAM-1 but not ICAM-1 expression ... Forskolin plus IBMX selectively inhibits TNF induced increases in ELAM-1 and VCAM-1 mRNA, indicating that the action of cAMP is to block synthesis of these molecules ... However, our findings suggest that pharmacological elevations of cAMP in EC, by inhibiting TNF induced synthesis of ELAM-1 and VCAM-1, could serve to limit inflammation
Delomenie et al., Exp Cell Res 1993 : Our results showed that IL-1 beta, tumor necrosis factor (TNF)alpha, and MECIF activity induced the expression of ELAM-1 on HEC membrane while transforming growth factor beta ( TGF beta ), IL-6, and gamma-interferon ( IFN-gamma ) showed no effect
Marui et al., J Clin Invest 1993 : In a distinct pattern, PDTC partially inhibited E-selectin gene expression in response to TNF alpha but not to LPS, IL-1 beta, or PIC
Petzelbauer et al., J Immunol 1993 (Dermatitis) : Endothelial-leukocyte adhesion molecule-1 ( ELAM-1 ) expression induced at 6 and 24 h by TNF or IL-1, is restricted to the venular side of the capillary loop and to the venules proper ... These results with DMEC differ from human umbilical vein EC analyzed in parallel, which are completely CD36- and show transient ELAM-1 and sustained VCAM-1 expression in response to TNF and IL-1
Hauser et al., J Immunol 1993 : Venous and arterial large vessel endothelial cells ( EC ) were compared for their constitutive and TNF-alpha induced expression of the cell-surface adhesion molecules ICAM-1 and -2, VCAM-1 and ELAM-1 by FACS analysis ... TNF-alpha increases the expression of ICAM-1, but not ICAM-2, and induces the expression of ELAM-1 on both EC types
Tabibzadeh et al., J Clin Endocrinol Metab 1994 : Expression of E-selectin on endothelial cells was induced only by IL-1 alpha, not by IFN gamma or TNF alpha
Varagunam et al., Nephrol Dial Transplant 1993 (Polyarteritis Nodosa...) : AECA binding was not enhanced following upregulation of endothelial ICAM-1 and ELAM-1 by TNF alpha
Renard et al., Int J Cancer 1994 (Melanoma...) : TNF alpha induced increased expression of ELAM-I and VCAM-I adhesion molecules on intratumoral endothelial cells
Thornhill et al., Scand J Immunol 1993 : TNF-stimulation also induced E-selectin expression on EA-hy-926 and HUVEC and an accompanying increase in neutrophil ( PMN ) binding
Mackay et al., J Exp Med 1993 : This finding correlated with the exclusive activity of TNF-R55 in the TNF-alpha dependent regulation of the expression of the intercellular adhesion molecule type 1 ( ICAM-1 ), E-selectin , and vascular cell adhesion molecule type 1 ( VCAM-1 )
Lee et al., J Dermatol Sci 1995 : We have demonstrated that stimulation of HDMEC with IL-1 alpha or TNF alpha leads to transient E-selectin induction which disappears after 48 h, but stimulation of HDMEC with IFN-gamma resulted in delayed E-selectin induction which was seen at 48 h of incubation and persisted until 72 h after stimulation
Klein et al., Pathobiology 1995 : In previous studies, we have shown that IL-1 beta and TNF alpha increase the expression of E-selectin and ICAM-1 on the cytoplasmatic membranes of HUVEC and human adult EC from the saphenous vein and femoral artery in a similar fashion
Neumann et al., J Immunol 1996 : In the lungs, but not in other organs, transient E-selectin expression was induced by TNF within 0.5 h and peaked at 4 h ... The TNF induced expression of VCAM-1 and E-selectin was found to be exclusively controlled by the 55-kDa TNF-receptor ( TNFRp55 ) as demonstrated by analysis of TNFRp55-/- mice ... Together, the data suggest that in vivo the 55-kDa TNF receptor mediates the induction of VCAM-1 and E-selectin expression and is critically involved in the control of leukocyte organ infiltration
Rabinovici et al., Circ Res 1996 : Furthermore, TNF-alpha inhibition prevented the upregulation of lung tissue IL-1 beta, IL-6, cytokine induced neutrophil chemoattractant, and E-selectin ( ELAM-1 ) but not intercellular adhesion molecule-1 mRNAs in response to IL-2
Laing et al., J Rheumatol 1995 : PUVA led to significant dose dependent decreases in the expression of VCAM-1 and E-selectin that had been induced with TNF before PUVA treatment
Chaudière et al., C R Seances Soc Biol Fil 1995 : TNF-alpha alone induces the endothelial release of Interleukin-8 (Il-8) as well as the expression of P- and E-selectin
Wheeler-Jones et al., FEBS Lett 1996 : Inhibition of thrombin induced p42 mapk activation was paralleled by an inhibitory effect of PD98059 on thrombin-driven PG12 generation but not on vWF secretion or IL-1 alpha/TNF alpha induced E-selectin expression
Griffioen et al., Blood 1996 (Inflammation...) : Also, the induction of vascular EC adhesion molecule-1 (VCAM-1) and E-selectin by TNF alpha was significantly inhibited by prior exposure to bFGF
Weber et al., Immunol Res 1996 : We demonstrate that the PTK inhibitors herbimycin A or genistein suppress induction of endothelial VCAM-1 and E-selectin , as well as subsequent monocytic cell adhesion to endothelial cells stimulated by TNF
Cunningham et al., Infect Immun 1996 : With Escherichia coli LPS, tumor necrosis factor alpha activation requires membrane bound CD14 and E-selectin expression requires soluble CD14 ( sCD14 )
Gijbels et al., Am J Pathol 1996 (Chronic Disease...) : Tumor necrosis factor-alpha may lead to the expression of E-selectin on endothelial cells, facilitating interleukin-4 mediated eosinophil transendothelial migration
Morandini et al., Am J Physiol 1996 : The expression of E-selectin induced by tumor necrosis factor (TNF) on the surface of human umbilical vein endothelial cells ( HUVEC ) was partially inhibited by an increase in the level of adenosine 3',5'-cyclic monophosphate ( cAMP ), produced by forskolin or cholera toxin combined with the type IV phosphodiesterase inhibitor rolipram and the protein kinase A agonist phosphorothioate analogue of cAMP SpcAMPS ... In addition to their partial inhibitory effect on the TNF induced surface expression of E-selectin on HUVEC, the forskolin-rolipram combination and SpcAMPS strongly inhibited the release of soluble E-selectin from these cells ; the release of soluble ICAM-1 and VCAM-1 was unaffected by these agents
Gedeit et al., Crit Care Med 1996 : Tumor necrosis factor induced E-selectin expression on vascular endothelial cells ... TNF induced E-selectin expression of the endothelial cells, with and without blocking antibodies, was then determined using indirect immunofluorescence and flow cytometry ... Blocking of either CD120a or CD120b receptors individually resulted in inhibition of TNF induced E-selectin expression on human umbilical vein endothelial cells ... When both antibodies were added, the inhibition of TNF induced E-selectin expression was synergistic ... Both CD120a and CD120b receptors are involved in TNF induced E-selectin expression on human umbilical vein endothelial cells ... Blocking of both or one receptor type can reduce or totally inhibit expression of E-selectin on human umbilical vein endothelial cells, but the response is dependent on both TNF and antibody concentrations
Miki et al., Cell Immunol 1996 : Histamine enhanced the TNF-alpha induced expression of E-selectin and ICAM-1 on vascular endothelial cells ... Tumor necrosis factor-alpha (TNF-alpha) induces the expression of E-selectin and intercellular adhesion molecule-1 ( ICAM-1 ) on human umbilical vein endothelial cells ( HUVEC ) ... In this report, we show that histamine concentration-dependently enhances the TNF-alpha induced expression of E-selectin and ICAM-1 on HUVEC
Adamson et al., Cell adhesion and communication 1996 : Stimulation of HUVEC with IL-1 alpha, TNF alpha or LPS for between 2 and 6h followed by removal or neutralisation of IL-1 alpha, TNF alpha or LPS and incubation in new media up to 6h resulted in identical levels of E-selectin expression at 6h, as cells which had been continuously stimulated for 6h with IL-1 alpha, TNF alpha or LPS
Syrbu et al., Exp Lung Res 1996 (Disease Models, Animal...) : The ELAM inducing activity of pure TNF alpha , however, was about 1/2 that of BALF60 containing equivalent concentrations of TNF alpha ... The time courses for ICAM and ELAM stimulation with pure TNF alpha or BALF60 containing equivalent levels of TNF alpha were the same
May et al., Br J Pharmacol 1996 : Although similar effects were seen on phorbol 12-myristate, 13-acetate ( PMA ) -induced expression, this was not due to inhibition of protein kinase C ( PKC ) activity as the selective inhibitors of PKC, bisindolylmaleimide ( BIM ), Ro31-7549 or Ro31-8220 did not affect IL-1 alpha- or TNF alpha induced E-selectin expression at concentrations which maximally inhibited PMA induced expression
Serrano et al., Am J Physiol 1996 : Tumor necrosis factor-alpha ( TNF-alpha ; 10 ng/ml ) increased endothelial ICAM-1, E-selectin , and VCAM-1 ; under these conditions, acidosis with 20 % CO2 blunted both ICAM-1 and E-selectin surface expression compared with 5 % CO2-, TNF-alpha treated cells
Klein et al., Pathobiology 1995 : In previous studies we have shown that IL-1 beta and TNF-alpha increase the expression of ICAM-1, E-selectin and VCAM-1 on the cytoplasmatic membranes of HUVECs, HSVECs and HAFECs ( ECs from human umbilical vein, saphenous vein and femoral artery, respectively )
Yamawaki et al., J Dermatol Sci 1996 : UVB radiation suppresses the TNF-alpha induced expression of E-selectin and ICAM-1 on cultured human umbilical vein endothelial cells
Tonnel et al., Ann N Y Acad Sci 1996 (Asthma...) : When supernatants of alveolar macrophages, recovered from patients exhibiting a late asthmatic response after allergen exposure, were tested on HUVEC cultures, a TNF alpha dependent ICAM-1 and E-selectin overexpression was observed
Rice et al., Anal Biochem 1996 : The effects of IL-1 beta, TNF alpha, LPS, and an LPS conditioned plasma product on E-selectin expression were characterized
Kunkel et al., Circ Res 1996 : TNF-alpha treatment induces expression of E-selectin and increases expression of P-selectin on endothelial cells
Henseleit et al., J Pathol 1996 (Dermatitis, Allergic Contact...) : LPS and tumour necrosis factor-alpha (TNF-alpha) , but not interleukin-4 (IL-4) or interferon-gamma (IFN-gamma), induced a transient expression of E-selectin , both when injected in vivo and when added to endothelial cell lines in vitro
Gille et al., J Clin Invest 1997 (Inflammation) : To determine modes of retinoid action in the modulation of inflammatory responses, we explored effects of all-trans-retinoic acid ( t-RA ) on the TNFalpha induced expression of vascular cell adhesion molecule-1 ( VCAM-1 ), intercellular adhesion molecule-1 ( ICAM-1 ), and E-selectin in cultured human dermal microvascular endothelial cells ... Pretreatment with t-RA specifically prevented TNFalpha induced VCAM-1 expression, but not ICAM-1 and E-selectin induction
Li et al., Int Arch Allergy Immunol 1997 : Failure to block biosynthesis of E-selectin and ICAM-1 induced by TNF-alpha and IL-1 beta indicates the inhibitory effect exerted by serotonin was selective in nature
Millan et al., Transplantation 1997 : Soluble tumor necrosis factor (TNF) alpha receptor inhibited E-selectin induced by TNF alpha, but not by U937 cells, and mRNA and protein on EC in Mo-EC mixtures cocultured at 1 : 1 ratios were not significantly reduced ... The TNF alpha inhibitor did reduce E-selectin expression ( 30-40 % ), as well as induced chemokine gene expression ( 80 % ), at higher Mo-EC ratios
Savage et al., J Pathol 1997 : Expression of E-selectin on glomerular endothelial cells ( ECs ) was induced by interleukin-1 (IL-1), tumour necrosis factor (TNF) , interferon-gamma (IFN-gamma) and granulocyte/ macrophage-colony stimulating factor ( GM-CSF ) ; this induction was inhibited by transforming growth factor beta ( TGF beta ) and by IL-4
van Setten et al., Kidney Int 1997 (Hemolytic-Uremic Syndrome) : Upon stimulation with TNF alpha the cells expressed the endothelial-specific adhesion molecule E-selectin
Kaplanski et al., J Immunol 1997 (Inflammation) : Although IL-1 and TNF-alpha also induce IL-8 and E-selectin , the thrombin effects in these experiments were not mediated by those cytokines, since neither IL-1 receptor antagonist nor anti-TNF-alpha Ab inhibited the effects of thrombin
Lou et al., J Neuroimmunol 1997 : TBP I completely abolished TNF induced IL-6 production and E-selectin induction, while it partially inhibited TNF induced IL-8 production and up-regulation of ICAM-1 and VCAM-1
Kimura et al., J Ethnopharmacol 1997 : The IC50 for the TNF-alpha induced ELAM-1 and ICAM-1 expressions were 1.5 x 10 ( -5 ) M and 3.1 x 10 ( -5 ) M, respectively ... In addition, protein C-kinase ( PKC ) inhibitor H7 also inhibited the ELAM-1 and ICAM-1 expressions induced by IL-1 beta and TNF-alpha
Erl et al., Am J Physiol 1997 : TCP succinate ( 200 microM, 24 h ) reduced TNF induced VCAM-1 and E-selectin expression from a specific mean fluorescence intensity of 151 +/- 28 to 12 +/- 4 channels and from 225 +/- 38 to 79 +/- 21 channels, respectively
Min et al., J Immunol 1997 : TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways ... Transient overexpression of N-terminal truncated c-Jun or catalytically inactive Jun N-terminal kinase (JNK) 1 and 2 inhibits TNF induced transcription of an E-selectin but not a kappa B promoter-reporter gene ... Transient overexpression of the TRAF2 adaptor protein can activate NF-kappaB and endogenous JNK, whereas N-terminal truncated TRAF2 protein blocks TNF induced NF-kappa B and JNK activation as well as E-selectin promoter-reporter gene transcription ... Transient overexpression of RAC1 or CDC42, but not RAS, constitutively activates JNK and augments TNF induced E-selectin transcription
Yaron et al., EMBO J 1997 : Microinjection of the inhibitory peptides into stimulated cells abolished NF-kappa B activation in response to TNF alpha and the consequent expression of E-selectin , an NF-kappa B-dependent cell-adhesion molecule
Horie et al., J Immunol 1997 : A dual radiolabeled mAb technique was used to quantify constitutive and TNF-alpha induced expression of ICAM-1, VCAM-1, E-selectin , and P-selectin in different vascular beds ( lung, heart, stomach, mesentery, small intestine, large intestine, and muscle ) in wild-type and SCID mice
Shen et al., J Virol 1997 : TNF-alpha significantly enhanced WNV induced increases in E-selectin , P-selectin, ICAM-1, and VCAM-1 expression, while IFN-gamma enhanced WNV induced ICAM-1 expression
Hauser et al., Br J Pharmacol 1997 : 5. The data demonstrate that apart from its antiproliferative effects on lymphocytes, MPA enhances TNF alpha induced VCAM-1 and E-selectin surface expression on EC by selectively increasing the mRNA-stability of these cell adhesion molecules
Hirata et al., Am J Respir Cell Mol Biol 1998 (Lung Neoplasms) : TNF-alpha and IL-1beta increased the expression of ICAM-1, E-selectin , and VCAM-1, whereas IL-4 induced only that of VCAM-1
Lockyer et al., Circ Res 1998 : We have generated populations of endothelial cells expressing wild-type and a proteolysis-resistant mutation of IkappaB that is lacking the 36 N-terminal amino acids ( IkappaBdeltaN ) in order to examine the effects of expression of the mutated IkappaB on tumor necrosis factor-alpha (TNF-alpha) induced E-selectin and ICAM-1 expression
Cominacini et al., J Hypertens 1997 : The addition of lacidipine to human umbilical vein endothelial cells significantly reduced the expression of ICAM-1, VCAM-1 and E-selectin induced by TNF-alpha alone or with oxidized LDL ( P < 0.001 )
Anrather et al., J Immunol 1997 : However, thrombin ( 3-10 U/ml ) stimulated a 10-fold enhancement in the ability of TNF ( 0.3-1.0 ng/ml ) to induce E-selectin surface expression ... Similar potentiation of TNF induced NF-kappaB activity and E-selectin transcription by thrombin was observed in experiments utilizing luciferase reporter constructs expressed in bovine aortic EC
Kräling et al., In Vitro Cell Dev Biol Anim 1998 : Tumor necrosis factor-alpha induced expression of E-selectin was similar in cells at Passages 3, 6, and 12, indicating that the cells maintained responsiveness to cytokines over several weeks
Spiecker et al., J Leukoc Biol 1998 : The NO donors, but not 8-bromo-cGMP, decreased tumor necrosis factor alpha (TNF-alpha) induced VCAM-1, ICAM-1, and E-selectin expression by 11-70 %
Blease et al., Br J Pharmacol 1998 : 2. Tumour necrosis factor-alpha (TNF-alpha) induced intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin expression were measured on HLMVEC monolayers at 6 h by a specific ELISA technique in the presence of different combinations of medium, rolipram, ORG 9935 and salbutamol ... 3. Rolipram in combination with salbutamol, but neither agent alone, inhibited TNF-alpha induced E-selectin expression, whilst ICAM-1 and VCAM-1 expression were not affected
Etter et al., Cytokine 1998 : Among them, E-selectin , which is expressed in response to interleukin 1 (IL-1) or tumour necrosis factor alpha (TNF-alpha) , provides rolling adhesion of the circulating leukocytes, a transient and reversible interaction that initiates leukocyte extravasation
Moutet et al., Free Radic Biol Med 1998 (Inflammation) : These two GPx mimics were also found to be the most efficient inhibitors of the TNFalpha induced endothelial expression of P- and E-selectin and of the TNFalpha- or interleukin1 induced endothelial release of interleukin-8
Stannard et al., Atherosclerosis 1998 : Finally, apo E-DMPC vesicles were also unable to suppress TNF-alpha induced upregulation of E-selectin or intercellular adhesion molecule-1 ( ICAM-1 )
Paulose et al., Microb Pathog 1998 : Mobility shift assays and Northern blot analyses further show that the supernatant from TPV infected cells inhibited TNF-alpha induced activation of the nuclear transcription factor-kappa B ( NF-kappa B ) and transcriptional activation of the E-selectin , VCAM-1 and ICAM-1 genes
Yamamoto et al., Int Arch Allergy Immunol 1998 : HNMEC differed from human umbilical vein endothelila cells in that ( 1 ) maximal upregulation of ICAM-1 expression induced by IL-1beta or TNF-alpha required more time ( 2 ) TNF-alpha was more potent than IL-1beta in VCAM-1 expression, and ( 3 ) dexamethasone inhibited the upregulation of E-selectin expression alone
Pober et al., Pathol Biol (Paris) 1998 : TNF initiates transcription of the E-selectin gene by activation of the transcription factors NF-kappa B and c-Jun/ATF-2
Nakada et al., Cell adhesion and communication 1998 : A neutralizing anti-TNF monoclonal antibody ( cA2 ) was used to study the down regulation of TNF induced E-selectin , vascular cell adhesion molecule-1 ( VCAM-1 ) and intercellular adhesion molecule-1 ( ICAM-1 ) on cultured human umbilical vein endothelial cells ( HUVECs )
Xu et al., J Biol Chem 1998 : Using highly specific antisense oligonucleotides that target the mRNA encoding c-Raf kinase and Ha-Ras, we show here that inhibition of c-raf and Ha-ras expression blocks the up-regulation of E-selectin and vascular adhesion molecule-1 induced by TNFalpha in endothelial cells ... Furthermore, antisense inhibition of JNK2 also blocked TNFalpha mediated induction of E-selectin , whereas PD98059 ( mitogen activated protein kinase kinase 1 and 2 inhibitor ) had no effect on this process ... These results indicate that TNFalpha induction of E-selectin and vascular adhesion molecule-1 in endothelial cells occurs through signaling pathways that are, at least in part, dependent on c-Raf kinase, Ha-Ras, and JNK2
Boyle et al., Circulation 1998 (Inflammation) : As measured with the use of an enzyme linked immunosorbent assay, TNF-alpha , IL-1, and LPS each induced a significant increase in surface expression of E-selectin in cultured human umbilical vein endothelial cells ( HUVECs ) compared with HUVECs treated with medium alone
Kalogeris et al., Am J Physiol 1999 : TNF stimulated expression of both intercellular adhesion molecule-1 and E-selectin in HUVECs, but in HUAECs, only intercellular adhesion molecule-1 was increased