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PGF — TNF

Text-mined interactions from Literome

Skarzynski et al., Biol Reprod 2000 : The aims of the present study were to determine the cell types in the endometrium ( epithelial or stromal cells ) responsible for the secretion of PGF ( 2alpha ) in response to TNFalpha , and the intracellular mechanisms of TNFalpha action ... Although an NO synthase (NOS) inhibitor ( L-NAME ) reduced TNFalpha stimulated PGF ( 2alpha ) production, an inhibitor of phosphodiesterase augmented the actions of TNFalpha and S-NAP ( P < 0. 05 )
Noguchi et al., J Periodontal Res 2001 (Periodontal Diseases) : IL-6 mRNA was expressed in PGF2alpha stimulated HGF, and PGF2alpha increased IL-6 mRNA levels induced by IL-1beta and TNFalpha
Murakami et al., Theriogenology 2001 : To determine the physiological significance of tumor necrosis factor-alpha (TNFalpha) in the regulation of endometrial prostaglandin ( PG ) release in cattle, we investigated the effects of TNFalpha on the secretion of PGE2 and PGF2alpha by bovine endometrium during the estrous cycle ... Although TNFalpha stimulated both PGE2 and PGF2alpha secretion during the entire period of the estrous cycle, the level of stimulation of TNFalpha on PGE2 output by the bovine endometrium does not show the same cyclical changes as that shown on PGF2alpha output
Sato et al., Eur J Obstet Gynecol Reprod Biol 2002 : IL-1beta and TNF-alpha both stimulated production of PGE ( 2 ) and 6-keto-PGF ( 1alpha ) in a concentration dependent manner
Okuda et al., Domest Anim Endocrinol 2002 : Furthermore, our recent study has shown that IFN-tau suppresses the action of TNF-alpha on PGF ( 2alpha ) synthesis by the bovine endometrium in vitro, suggesting that IFN-tau plays a luteoprotective role by inhibiting TNF-alpha induced PGF ( 2alpha ) production in early pregnancy
Okuda et al., Biol Reprod 2004 : The aims of the present study were to determine the effect of interferon-tau ( IFNtau ) on TNFalpha stimulated PGF2alpha synthesis and the intracellular mechanisms of TNFalpha and IFNtau action in the stromal cells ... When cultured bovine stromal cells were exposed to TNFalpha ( 0.006-0.6 nM ) for 24 h, the production of PGF2alpha and cyclooxygenase (COX)-2 gene expression were stimulated by TNFalpha ( 0.06-0.6 nM, P < 0.05 ) ... Moreover, a specific COX-2 inhibitor ( NS-398 ; 5 nM ) blocked the stimulatory effect of TNFalpha on PGF2alpha production ( P < 0.05 ) ... The overall results indicate that the stimulatory effect of TNFalpha on PGF2alpha production is mediated by the up-regulation of COX-2 gene expression and suggest that one of the mechanisms of the inhibitory effect of IFNtau on luteolysis is the inhibition of TNFalpha action in PGF2alpha production in the stromal cells by the down-regulation of COX-2 gene expression stimulated by TNFalpha
Murakami et al., J Reprod Dev 2003 : In primary culture of frozen and unfrozen endometrial cells, OT strongly stimulated PGF ( 2alpha ) production in epithelial cells, and TNFalpha strongly stimulated PGF ( 2alpha ) production in stromal cells ( P < 0.05 )
Fujino et al., Biochem Biophys Res Commun 2004 : TNF-alpha reporter activity in FPB cells is stimulated by PGF2alpha and this is decreased by pretreatment with a chelator of intracellular calcium or by a gap junction inhibitor ... It, therefore, appears that PGF2alpha stimulated TNF-alpha reporter activity in FPB cells is amplified by a Rho dependent mechanism involving calcium, gap junctions, and PKC
Mitchell et al., J Clin Endocrinol Metab 2005 : IL-1beta and TNFalpha caused concentration dependent increases in 9alpha,11beta-PGF ( 2 ) production in human amnion and choriodecidual explants
Skarzynski et al., Domest Anim Endocrinol 2005 : TNFalpha in combination with interferon-gamma reduced progesterone ( P4 ) secretion, increased PGF2alpha and leukotriene C4 ( LTC4 ) production, and induced apoptosis of the luteal cells in vitro
Edwards et al., Inflamm Bowel Dis 2006 (Disease Models, Animal...) : Gi alpha2-/- myofibroblasts from the small intestine and colon both released asymptotically equal to 50 % less arachidonate and 3- to 7-fold less PGE2 and 6-keto PGF1alpha in response to adenosine triphosphate, thrombin, tumor necrosis factor-alpha , or lipopolysaccharide, in a partially cyclooxygenase (COX)-2 dependent manner
Cannon et al., Reproduction 2006 : Tumor necrosis factor-alpha (TNF-alpha) reduced DMalpha mRNA concentrations in cultured luteal cells in the presence of LH or PGF ( 2alpha )
Blitek et al., Reprod Domest Anim 2006 : A time dependent effect of TNFalpha ( 10 ng/ml ) on PGF ( 2alpha ) release was observed in stromal and luminal epithelial cells ... Moreover, TNFalpha increased PGF ( 2alpha ) secretion from both endometrial cell types with effective concentrations of 1 ( p < 0.05 ), 10 and 50 ng/ml ( p < 0.01 ) ... Summarizing, TNFalpha induces both PGs secretion from cultured porcine endometrium, but preferentially stimulates PGF ( 2alpha ) release from luminal epithelial cells
Yoo et al., Arthritis Rheum 2009 (Arthritis, Experimental...) : Exogenous PlGF specifically increased the production of TNFalpha and IL-6 in mononuclear cells from RA patients ( but not those from healthy controls ) via a calcineurin dependent pathway ... A novel anti-flt-1 hexapeptide, GNQWFI, abrogated the PlGF induced increase in TNFalpha and IL-6 production, and also suppressed CII induced arthritis and serum IL-6 concentrations in mice
Kim et al., Osteoarthritis Cartilage 2009 (Low Back Pain) : SB202190 successfully suppressed IL-6, IL-8, PGE2, and PGF2alpha secretion in macrophage exposed AF cells in response to TNF-alpha
Siemieniuch et al., Experimental biology and medicine (Maywood, N.J.) 2009 : TNFalpha stimulated PGF ( 2alpha ) secretion on Day 0 ( onset of estrus = Day 0 ) and Days 2-3, in both the ampulla and isthmus, but on Days 18-20 only in ampulla
Brenneis et al., J Biol Chem 2011 (Disease Models, Animal...) : Interestingly, we found that activation of E-prostanoid ( EP ) 2 and EP4 receptors, but not EP1, EP3, PGI(2) receptor ( IP ), thromboxane A(2) receptor ( TP ), PGD(2) receptor ( DP ), and PGF ( 2 ) receptor ( FP ), efficiently blocked LPS induced tumor necrosis factor a (TNFa) synthesis and COX-2 and mPGES-1 induction as well as prostaglandin synthesis in spinal cultures
Siemieniuch et al., Pol J Vet Sci 2010 : TNFalpha at a dose of 1 ng/ml significantly increased PGF2alpha secretion at estrus ( P < 0.01 ) and PGE2 secretion at diestrus ( P < 0.001 ) after 12h incubation
Franczak et al., Theriogenology 2012 : We studied the effect of tumor necrosis factor a (TNFa) , interleukin 1ß (IL1ß) and interleukin 6 (IL6) on : 1 ) endometrial release of prostaglandin F2a (PGF2a) , 2 ) expression of the terminal enzyme of PGF2a synthesis -- PGF synthase mRNA (PGFS mRNA), 3 ) secretion of PGF ( 2 ) a metabolite -- 13,14-dihydro-15-keto PGF2a ( PGFM ) by the endometrium and 4 ) presence and activity of endometrial NAD dependent 15-hydroxyprostaglandin dehydrogenase ( 15-PGDH )
Fletcher et al., Ann Surg 1993 (Acidosis) : TNF stimulated synthesis of ( a ) TXB2 ( 71 +/- 30 pg/ml, mean +/- SE at base vs. 117 +/- 18 at 4 hr, p < 0.02 ) ; ( b ) PGE2 ( 70 +/- 6 pg/ml at base vs. 231 +/- 68 at 4 hr, p < 0.02 ) ; ( c ) 6PGF ( 52 +/- 6 pg/ml at base vs. 250 +/- 80 at 4 hr, p < 0.02 )