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EGF — VAV2
Text-mined interactions from Literome
Tamás et al., Cell Signal 2001
:
In addition, introducing point mutations into the SH2 domain of green fluorescens protein ( GFP ) -Vav2 fusion protein leads to the loss of
Vav2 tyrosine phosphorylation in
response to
EGF ... These data suggest that membrane targeting of Vav2 through its SH2 domain is an important event in the phosphorylation and activation of
Vav2 in
response to
EGF
Tamás et al., J Biol Chem 2003
:
Mechanism of
epidermal growth factor regulation of
Vav2 , a guanine nucleotide exchange factor for Rac ... Treatment of cells with
EGF results in stimulation of exchange activity of
Vav2 as measured on Rac ; however, the intensity of the exchange activity does not show any correlation with the level of Vav2 tyrosine phosphorylation ... These results suggest that
EGF regulates
Vav2 activity basically through phosphatidylinositol 3-kinase activation, whereas tyrosine phosphorylation of Vav2 may rather be necessary for mediating protein-protein interactions
Marcoux et al., Oncogene 2003
:
EGF receptor
mediates adhesion dependent activation of the Rac GTPase : a role for phosphatidylinositol 3-kinase and
Vav2