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CD4 — IDO1

Text-mined interactions from Literome

Li et al., J Invest Dermatol 2006 : We have previously demonstrated that IDO expressed in fibroblasts causes bystander CD4 ( + ) T cell damage as well as THP-1 cell damage by apoptosis
Boasso et al., Blood 2007 (HIV Infections) : Here, we show that IDO mRNA expression is elevated in peripheral blood mononuclear cells ( PBMCs ) from HIV ( + ) patients compared with uninfected healthy controls ( HCs ), and that in vitro inhibition of IDO with the competitive blocker 1-methyl tryptophan ( 1-mT ) results in increased CD4 ( + ) T-cell proliferative response in PBMCs from HIV infected patients
Saito et al., J Assist Reprod Genet 2007 (Pregnancy Complications) : Recent data show that CD4 ( + ) CD25 ( + ) Treg cells play essential roles in the induction and maintenance of tolerance, and that they augment the IDO activity in dendritic cells and macrophages
Ryu et al., Invest Ophthalmol Vis Sci 2007 : IDO expression and its apoptotic effects on CD4 ( + ) T cells were also investigated after IFN-gamma treatment
Kim et al., J Leukoc Biol 2009 : We show that this selective suppression of CD4 ( + ) T cells by 4-1BB triggering in vivo is mediated mainly by induction of indoleamine 2,3-dioxygenase (IDO) in an IFN-gamma dependent manner ... Collectively, these data indicate that 4-1BB dependent suppression of SEA-specific CD4 ( + ) T responses was mediated mainly by IFN-gamma dependent IDO induction and partially by TGF-beta
Paveglio et al., Am J Respir Cell Mol Biol 2011 (Disease Models, Animal...) : Upon inhalation of formalin fixed Aspergillus fumigatus hyphal antigens, the overexpression of IDO from airway epithelial cells of these mice reduced the number of CD4 ( + ) T cells within the inflamed lung and impaired the capacity of antigen-specific splenic CD4 ( + ) effector T cells to secrete the cytokines IL-4, IL-5, IL-13, and IFN-?
Huang et al., International journal of molecular sciences 2012 : Since the CD4 molecule plays a central role in the onset and regulation of antigen-specific immune responses, and T cell is sensitive in the absence of tryptophan, we hypothesize that IDO may reduce cell surface CD4 expression ... To test this hypothesis, an adenoviral vector based construct IDO-EGFP was generated and the effect of IDO-EGFP on CD4 expression was determined on recombinant adenoviral infected C8166 and MT-2 cells, by flow cytometry and/or Western blot analysis
Li et al., J Reprod Immunol 2013 (Abortion, Spontaneous) : In our previous study, adenovirus mediated CTLA4Ig transgene ( Ad-CTLA4Ig ) therapy was demonstrated to improve pregnancy outcome in an abortion-prone mouse model by skewing the Th2/Th1 cytokine balance, expanding peripheral CD4 ( + ) CD25 ( + ) regulatory T cell populations and inducing indoleamine 2,3 dioxygenase (IDO) mRNA expression at the maternal-fetal interface
Ikemoto et al., Cell Immunol 2013 : In conclusion, DST allows induction of donor-specific tolerance which involves Foxp3 ( + ) CD4 ( + ) CD25 ( + ) T cells and IDO expression