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NOTCH1 — PTEN
Text-mined interactions from Literome
Whelan et al., Cell cycle (Georgetown, Tex.) 2007
:
In a previous study, we found that
Notch-1 signaling
resulted in increased
PTEN protein expression
Palomero et al., Nat Med 2007
(Disease Models, Animal...) :
Here we show that
NOTCH1 regulates the expression of
PTEN ( encoding phosphatase and tensin homolog ) and the activity of the phosphoinositol-3 kinase (PI3K)-AKT signaling pathway in normal and leukemic T cells
Silva et al., Haematologica 2010
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
Regulation of
PTEN by CK2 and
Notch1 in primary T-cell acute lymphoblastic leukemia : rationale for combined use of CK2- and gamma-secretase inhibitors
Liu et al., Urol Oncol 2013
(Carcinoma, Renal Cell...) :
Blocking
NOTCH1 signaling
resulted in the attenuation of proliferation, invasion, and migration, as well as
PTEN up-regulation with decreased AKT phosphorylation ... Our findings indicated that NOTCH1 receptor expression was up-regulated in CCRCC, and that
NOTCH1 could
regulate PTEN expression and the activity of the PI3K/AKT pathway via HES1 in 786-O and HKC cell lines
Pei et al., Basic Res Cardiol 2013
(Myocardial Reperfusion Injury) :
Moreover,
Notch1 blockade also reduced phosphorylation of endothelial NO synthase (eNOS) and Akt, and
increased expression of
PTEN , a key phosphatase involved in the regulation of Akt phosphorylation