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NFKB1 — NOTCH1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: NFKB1 — NOTCH1 (physical association, affinity chromatography technology) Guan et al., J Exp Med 1996*
• IRef Biogrid Interaction: NFKB1 — NOTCH1 (direct interaction, pull down) Guan et al., J Exp Med 1996*
• IRef Biogrid Interaction: NFKB1 — NOTCH1 (direct interaction, pull down) Wang et al., J Immunol 2001*
• IRef Hprd Interaction: NFKB1 — NOTCH1 (in vitro) Wang et al., J Immunol 2001*, Shin et al., EMBO J 2006*, Guan et al., J Exp Med 1996*
• IRef Hprd Interaction: NFKB1 — NOTCH1 (in vivo) Wang et al., J Immunol 2001*, Shin et al., EMBO J 2006*, Guan et al., J Exp Med 1996*
• IRef Intact Interaction: NFKB1 — NOTCH1 (physical association, anti tag coimmunoprecipitation) Shin et al., EMBO J 2006*
• IRef Ophid Interaction: NFKB1 — NOTCH1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., J Immunol 2001 : Human Notch-1 inhibits NF-kappa B activity in the nucleus through a direct interaction involving a novel domain ... We found that Notch ( IC ) localizes to the nucleus and that a region in the N-terminal portion of Notch ( IC ), not the six ankyrin repeats, is responsible for the inhibitory effects of Notch on NF-kappaB directed gene expression and NF-kappaB DNA binding activity
Cheng et al., J Immunol 2001 : Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells
Palaga et al., J Immunol 2003 : Inhibition of Notch activation dramatically decreases T cell proliferation in both CD4 and CD8 cells and blocks both NF-kappaB activity and IFN-gamma production in peripheral T cells
Poppema et al., Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2005 (Hodgkin Disease) : A key role is played by the presence of constitutive nuclear factor (NF)-kappaB , which is induced by LMP1, as well as by CD30, CD40, tumor necrosis factor (TNF)-alpha, and Notch1 interactions, and results in the upregulation of at least 45 genes including chemokines, cytokines, receptors, apoptotic regulators, intracellular signaling molecules, and transcription factors
Shin et al., EMBO J 2006 : Notch1 augments NF-kappaB activity by facilitating its nuclear retention ... Here, we examined the temporal relationship between Notch signaling and NF-kappaB induction during T-cell activation
Wang et al., Cancer Res 2006 (Neoplasm Invasiveness...) : In our earlier report, we showed that down-regulation of Notch-1 reduced nuclear factor-kappaB (NF-kappaB) DNA binding activity and matrix metalloproteinase-9 (MMP-9) expression ... Because NF-kappaB, VEGF, and MMPs are critically involved in the processes of tumor cell invasion and metastasis, we investigated the role and mechanism ( s ) by which Notch-1 down-regulation ( using molecular approaches ) may lead to the down-regulation of NF-kappaB , vascular endothelial growth factor ( VEGF ), and MMP-9, thereby inhibiting invasion of pancreatic cancer cells through Matrigel ... Consistent with these results, we found that the down-regulation of Notch-1 reduced NF-kappaB DNA binding activity and VEGF expression
Wang et al., Mol Cancer Ther 2006 (Pancreatic Neoplasms) : Because Notch-1 is known to cross-talk with another major cell growth and apoptotic regulatory pathway ( i.e., NF-kappaB ), we found that NF-kappaB is a downstream target of Notch because down-regulation of Notch reduced NF-kappaB activity
Aifantis et al., Cell cycle (Georgetown, Tex.) 2007 (Cell Transformation, Neoplastic...) : Our studies suggested that NFkappaB activation by Notch1 can be direct, as Notch1 can bind and activate the promoters of the RELB and NFkappaB2 factors and indirect, as Notch1 can form a complex with the NFkappaB kinase IKK
Palaga et al., Eur J Immunol 2008 : Taken together, stimulation of macrophages through the TLR signaling cascade triggered activation of Notch signaling, which in turn regulated gene expression patterns involved in pro-inflammatory responses, through activation of NF-kappaB
Mandinova et al., EMBO J 2008 : Conversely, Notch activation protects keratinocytes against apoptosis through a mechanism that is not linked to Notch induced cell cycle withdrawal or NF-kappaB activation
Yao et al., Dig Liver Dis 2009 (Stomach Neoplasms) : However, TNFalpha induced activation of NF-kappaB was not affected by over activated Notch-1
Monsalve et al., Eur J Immunol 2009 : We report here that Notch signaling increases both basal and LPS induced NF-kappaB activation, favoring the expression of genes implicated in the inflammatory response, such as the cytokines TNF-alpha and IL-6, or enzymes, such as iNOS
Wang et al., J Cell Biochem 2010 (Neoplasm Invasiveness...) : Consistent with these results, we found that the down-regulation of Notch-1 or Jagged-1 led to decreased expression and the activity of NF-kappaB downstream genes such as MMP-9, VEGF, and uPA, contributing to the inhibition of cell migration and invasion
Cao et al., J Neurosci Res 2010 (Gliosis) : It is concluded that Notch-1 signaling can trans-activate NF-kappaB/p65 by amplifying NF-kappaB/p65 dependent proinflammatory functions in activated microglia
Oswald et al., Mol Cell Biol 1998 : In transient-transfection assays we show that truncated Notch-1 strongly induces NF-kappaB2 promoter activity