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GATA2 — NOTCH1

Text-mined interactions from Literome

Kumano et al., Blood 2001 (Leukemia, Erythroblastic, Acute) : These results indicate that GATA-2 activity is necessary for the Notch signaling in hematopoietic cells
Schneider et al., J Pathol 2004 (Burkitt Lymphoma...) : In some leukaemic cell lines, the effect of Notch signalling is mediated by the early transcription factor GATA-2
Robert-Moreno et al., Development 2005 : Consistent with a role for Notch1 in regulating Gata2 , we observe increased expression of this gene in 32D cells expressing activated Notch1 ... Taken together, these data strongly suggest that activation of Gata2 expression by Notch1/RBPjkappa is a crucial event for the onset of definitive hematopoiesis in the embryo
Guiu et al., J Exp Med 2013 : Together, our findings show that Notch activation in the AGM triggers Gata2 and Hes1 transcription, and next HES-1 protein represses Gata2, creating an incoherent feed-forward loop required to restrict Gata2 expression in the emerging HSCs