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CTNNB1 — FGF2
Text-mined interactions from Literome
Treichel et al., Genes Dev 2003
:
We present evidence that mBtd is required during early limb development to maintain, but not to initiate
Wnt/beta-catenin dependent
FGF , Shh, and BMP mediated signaling
Israsena et al., Dev Biol 2004
:
FGF2 increases
beta-catenin signaling through several different mechanisms including increased expression of beta-catenin mRNA, increased nuclear translocation of beta-catenin, increased phosphorylation of GSK-3beta, and tyrosine phosphorylation of beta-catenin ... Overexpression of
beta-catenin in the
presence of
FGF2 helps to maintain neural progenitor cells in a proliferative state
Hirabayashi et al., Development 2004
:
Overexpression of Wnt7a or of a stabilized form of
beta-catenin in mouse cortical NPC cultures induced neuronal differentiation even in the
presence of
Fgf2 , a self-renewal promoting factor in this system
Kanda et al., J Cell Biochem 2005
:
FGF-2 induced association of
beta-catenin with TCF-4 and up-regulation of fibronectin in IBE cells, but not in KDFyn cells ...
FGF-2 induced tyrosine phosphorylation of
beta-catenin , and association with TCF-4 was increased in IBE cells, but not in KDFyn cells
Maegawa et al., Development 2006
:
By contrast, when
FGF signaling is inhibited,
beta-catenin did not
induce goosecoid and chordin, repress bmp4 expression or induce a dorsal axis ... These results demonstrate that
FGF signaling is
necessary for
beta-catenin induction of the zebrafish organizer
Katoh et al., Cancer Biol Ther 2007
(Helicobacter Infections...) :
WNT-beta-catenin-TCF/LEF signaling
induces upregulation of MYC, CCND1, WISP1,
FGF20 , JAG1 and DKK1 genes
Ambrosetti et al., Mol Cell Biol 2008
:
FGF did not significantly
affect the activation of
beta-catenin , although it reduced both the expression of TCF/LEF factors and their induction by Wnt. Microarray analysis using osteoblasts treated with Wnt3a and FGF alone or in combination showed that about 70 % of the genes induced by Wnt3a were downregulated by combined FGF treatment
Shimizu et al., Mol Cell Biol 2008
:
We demonstrate that
FGF2 signaling through phosphatidylinositol 3 kinase activation inactivates glycogen synthase kinase 3beta ( GSK3beta ) and
leads to the accumulation of
beta-catenin in a manner different from that in the Wnt canonical pathway
Ding et al., J Cell Physiol 2010
:
To understand the importance of PI3-K activation,
activation of
Wnt/beta-catenin by
FGF-2 was investigated