◀ Back to CSE
CSE — DISC1
Text-mined interactions from Literome
Kim et al., Autophagy 2008
(Necrosis...) :
Reduction of Beclin 1 levels with beclin 1 siRNA inhibited
DISC formation and caspase-3/8 activation in
response to
CSE ... Conversely, transfection of Beas-2b with ho-1 siRNA augmented
CSE induced
DISC formation and increased intracellular reactive oxygen species formation ... Consistently, expression of IkappaB, the inhibitor of NFkappaB, increased
CSE induced
DISC formation ... In fibroblasts from beclin 1 heterozygous knockout mice, p65 phosphorylation was dramatically upregulated, while
CSE induced
DISC formation was inhibited, consistent with an anti-apoptotic role for NFkappaB and a pro-apoptotic role for Beclin 1
Park et al., J Toxicol Sci 2010
:
We demonstrated
cigarette smoke extract (CSE) induced
DISC formation in human lung fibroblasts ( MRC-5 ) ... We demonstrated that
CSE induces
DISC formation in MRC-5 using IP for Fas and IB for caspase 8