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IL10 — JAK1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Subramaniam et al., Biochem Biophys Res Commun 1999
:
Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells,
interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of
JAK 1 , 2 and 3, Tyk 2 and STAT 1, 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Tanuma et al., Blood 2001
:
Among cytokines tested, the inhibitory effect of PTPepsilonC is selective to IL-6- and
IL-10 induced
JAK-STAT signaling
Ding et al., J Immunol 2001
:
In this study, we characterized the differential receptor binding specificity, affinity, and
Janus kinase-STAT activation of cellular
IL-10 ( cIL-10 ) compared with viral IL-10 ( vIL-10 )
Stearns et al., Oncogene 2003
(Prostatic Neoplasms) :
IL-10E1 signaling
involves tyrosine phosphorylation of the IL-10R
JAK1 ( Janus kinase ) and TYK2 ( tyrosine kinase) receptor kinases and tyrosine phosphorylation of two tyrosine moieties ( Y57 and Y62 ) of a LIM domain of the IL-10E1 protein
To et al., Br J Cancer 2004
(Cell Transformation, Neoplastic...) :
The
interleukin mediated
Janus kinase ( JAK ) /STAT pathway plays a crucial role in carcinogenesis
Anderson et al., J Immunol 2005
:
Stimulation of PI-T ( Reg ) cells in vitro with
IL-10 induced
Jak1 and STAT3 activation, but not STAT5, suggesting that IL-10 is important, but not the only cytokine involved in the development of T cell tolerance
Valencia-Pacheco et al., Scand J Rheumatol 2006
(Lupus Erythematosus, Systemic) :
In addition, variable levels of
Jak-1 , Tyk-2, Stat-1, and Stat-3 activation were
induced by
IL-10 in PBMCs from SLE patients and controls, with no significant differences in protein phosphorylation or kinetics of activation
Horie et al., Microbiol Immunol 2007
(Burkitt Lymphoma) :
Exogenous
IL-10 lead rapidly to phosphorylation of
Jak1 and Tyk2 as transducers of signals of IL-10, and promoted growth of Akata cells in a dose dependent manner
Ngo et al., Nature 2011
(Burkitt Lymphoma...) :
The L265P mutant promoted cell survival by spontaneously assembling a protein complex containing IRAK1 and IRAK4, leading to IRAK4 kinase activity, IRAK1 phosphorylation, NF-?B signalling,
JAK kinase
activation of STAT3, and secretion of IL-6,
IL-10 and interferon-ß
Pattison et al., J Immunol 2012
:
The initial induction of
IL-10 was
independent of
JAK signaling ; however, inhibition of JAKs did reduce IL-10 secretion at later time points
Finbloom et al., J Immunol 1995
:
IL-10 induces the tyrosine phosphorylation of tyk2 and
Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes