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TNF — TUFM
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Park et al., Cytokine 2002
:
Here we focused on the
p43 induced
TNF production and determined its responsible signal pathway ... The
p43 induced
TNF production was mediated by the activation of MAPK family members, ERK and p38 MAPK, and by IkappaB degradation leading to the activation of NFkappaB ... The inhibitors for protein kinase C ( PKC ) and phospholipase C (PLC) prevented the
p43 induced
TNF production ... Together, the
p43 induced
TNF production was controlled by NFkB, p38 MAPK, and ERK that is dependent on the activities of PLC and PKC
Park et al., Am J Pathol 2005
:
In skin wound regions from mice,
tumor necrosis factor-alpha induced
p43 expression and secretion from macrophages recruited to the site