Gene interactions and pathways from curated databases and text-mining

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SRGN — TNF

Text-mined interactions from Literome

Piani et al., Microbes Infect 1999 : PPG inhibited the production of tumor necrosis factor-alpha and synergized with interferon-gamma to stimulate the production of nitric oxide by macrophages
Arlt et al., Oncogene 2001 : Here, we show that in HeLa cells TNFalpha induces expression of p22PRG1/IEX-1 in an NF-kappaB dependent fashion ... Blockade of NF-kappaB activation by various NF-kappaB inhibitors abolished TNFalpha induced p22PRG1/IEX-1 expression and increased the sensitivity to apoptosis induced by TNFalpha, an activating Fas-antibody or the anti-cancer drug etoposide
Draing et al., Eur J Immunol 2008 : TNF induction by Staphylococcus aureus or by Toll-like receptor (TLR)2 agonists ( di- and triacylated lipopeptides and LTA ) was also inhibited by PPG 1200, but not that induced by Escherichia coli or TLR4 agonists
Imoto-Tsubakimoto et al., Biochem Biophys Res Commun 2013 (Coronary Artery Disease...) : Serglycin was secreted from adipocytes, and tumor necrosis factor-a stimulated its expression and secretion in adipocytes