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LDHA — TNF

Text-mined interactions from Literome

Boussouar et al., Endocrinology 1999 : Tumor necrosis factor-alpha stimulates lactate dehydrogenase A expression in porcine cultured sertoli cells : mechanisms of action ... Inhibitors of protein synthesis ( cycloheximide ), gene transcription ( actinomycin D and dichlorobenzimidazole riboside ), tyrosine kinase ( genistein ), and protein kinase C ( bisindolylmaleimide ) abrogated completely ( actinomycin D, dichlorobenzimidazole riboside, cycloheximide, and genistein ) or partially ( bisindolylmaleimide ) TNFalpha induced LDH A mRNA expression ... These observations suggest that the stimulatory effect of TNFalpha on LDH A mRNA expression requires protein synthesis and may involve a protein tyrosine kinase and protein kinase C
Grataroli et al., Biol Reprod 2000 : Role of sphingosine in the tumor necrosis factor alpha stimulatory effect on lactate dehydrogenase A expression and activity in porcine Sertoli cells ... Together, the present data suggest that in primary Sertoli cell cultures, TNFalpha stimulating action on LDHA expression is partly exerted via sphingomyelin hydrolysis pathway, sphingosine being the active metabolite
Jurisic et al., Ann Hematol 2004 (Lymphoma, Non-Hodgkin) : In patients after administration of chemotherapy, TNF-alpha in a dose of 100 U/ml induced a significant increase ( p < 0.05 ) of LDH-M isotype activity, but not of LDH-H