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APOB — PLD3

Text-mined interactions from Literome

Gómez-Muñoz et al., Arterioscler Thromb Vasc Biol 2000 (Arteriosclerosis) : Stimulation of phospholipase D activity by oxidized LDL in mouse peritoneal macrophages ... Pretreatment of macrophages with the protein kinase C inhibitor Ro-32-0432 or downregulation of protein kinase C activity by prolonged incubation with 100 nmol/L 4beta-phorbol 12-myristate 13-acetate did not alter the stimulatory effect of oxidized LDL on PLD activation ... However, oxidized LDL stimulated tyrosine phosphorylation of several macrophage proteins, and preincubation of the macrophages with genistein, a tyrosine kinase inhibitor, blocked the activation of PLD by oxidized LDL ... In addition, pretreatment with orthovanadate, which inhibits tyrosine phosphatases, enhanced basal and oxidized LDL stimulated PLD activity ... Pretreatment of macrophages with pertussis toxin decreased the stimulatory effect of oxidized LDL, indicating that GTP binding proteins may also be involved in the activation of PLD by oxidized LDL
Natarajan et al., J Lipid Res 1995 (Arteriosclerosis) : To test this hypothesis, activation of PLD by OX-LDL was investigated in [ 3H ] myristic acid- or [ 32P ] orthophosphate labeled rabbit femoral artery smooth muscle cells ( RFASMC ) in the presence of 0.5 % ethanol or 0.05 % butanol ... To determine the mechanism ( s ) of OX-LDL induced PLD activation, the role of protein kinase C ( PKC ) and Ca2+ was investigated ... Pretreatment of [ 32P ] orthophosphate labeled RFASMC with known inhibitors of PKC such as staurosporine, calphostin-C, or H-7, had no effect on OX-LDL induced PLD activation ... In addition, exposure of RFASMC to sodium orthovanadate, an inhibitor of phosphatases, enhanced the OX-LDL mediated PLD activation ... The activation of PLD by OX-LDL generates second-messengers like PA and/or LPA which modulate mitogenesis