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CD33 — IL6

Text-mined interactions from Literome

Liu et al., Int J Hematol 2007 (Multiple Myeloma) : Interleukin 6 (IL-6) , a growth factor for myeloma cells, down-regulated CD33 , CD7, or CD56 expression in primary myeloma cells, as well as in Liu01 cells
Shamsasenjan et al., Int J Hematol 2009 (Multiple Myeloma) : IL-6 induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33+ myeloma cells ... As suggested by the lack of an increase in serum CRP values in CD33 ( + ) myelomas, IL-6 down-regulated the expression of CD33 in CD33 ( + ) myeloma cell lines along with the down-regulation of CEBPA gene expression ... It was confirmed that introduction of shRNA for MYC into a CD33 ( + ) myeloma cell line blocked the IL-6 induced down-regulation of CD33 and CEBPA expression