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SNAP25 — TNF

Text-mined interactions from Literome

Deakin et al., Cytokine 1995 : In addition, SNAP prevented the potentiation of IL-6 and the inhibition of TNF-alpha release by L-NIO
Wang et al., J Biol Chem 1997 : However, SNP and SNAP did not elevate cGMP levels in U937 cell cultures, and the cGMP analog, 8-bromo-cGMP, had no effect on TNF production ... H89, an inhibitor of cAMP dependent protein kinase, dose dependently increased TNF production in phorbol myristate acetate differentiated U937 cells in the absence ( 6.5-fold at 30 microM ; p = 0.035 ), but not in the presence ( p = 0.77 ) of SNAP ... Conversely, the cAMP analog dibutyryl cAMP ( Bt2cAMP ) blocked SNAP induced TNF production ( p = 0.001 ) ... SNP and SNAP ( 500 microM ) increased relative TNF mRNA levels by 57.5 % ( p = 0.045 ) and 66.2 % ( p = 0.001 ), respectively