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IFNG — MMP13

Text-mined interactions from Literome

Ala-aho et al., Oncogene 2000 (Cell Transformation, Neoplastic) : Here, we show, that interferon-gamma (IFN-gamma) markedly inhibits expression of MMP-13 by human cutaneous SCC cells ( UT-SCC-7 ) and by ras transformed human epidermal keratinocytes ( A-5 cells ) at the transcriptional level
Nold et al., Naunyn Schmiedebergs Arch Pharmacol 2003 : Whereas IL-18 and TNFalpha induced the protease, MMP-9 release was not mediated by IFNgamma
Ahmad et al., Ann Rheum Dis 2007 : IFNgamma potently suppressed IL1 induced expression of MMP13 and promoter activity ... p300 overexpression reversed IFNgamma inhibition of endogenous MMP13 mRNA expression and exogenous MMP13 promoter activity
Wang et al., World J Gastroenterol 2008 (Liver Cirrhosis) : Both Cpd 861 and IFN-gamma reduced the mRNA levels of collagen type III, MMP-2 and TGF-beta1
Nareika et al., Atherosclerosis 2009 (Atherosclerosis...) : Results showed that high glucose and IFN gamma had a synergistic effect on the expression of MMP-1, MMP-9 and IL-1 beta
Ahmad et al., Osteoarthritis Cartilage 2009 (Osteoarthritis) : Interferon-gamma (IFN-gamma) potently inhibits interleukin-1 (IL-1) induced MMP-13 expression in healthy chondrocytes
Mann et al., Ann Otol Rhinol Laryngol 1995 (Carcinoma, Squamous Cell...) : Supernatants of HNSCC cell lines SCC-25 and FADU stimulated with interleukin (IL)-1 alpha and IL-1 beta demonstrated modest induction of 92 kd GL production by zymogram analysis when compared with controls ; IL-2, IL-6, and interferon-gamma had no consistent effect on MMP production
Varga et al., Adv Exp Med Biol 1996 : Supplementation with tryptophan completely overcame the inhibitory effects of interferon-gamma on MMP mRNA expression and metalloproteinase secretion into the media ... These results indicate that oxidative tryptophan metabolism mediates the effects of interferon-gamma on MMP gene expression in human fibroblasts