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CSF3 — IFNG
Text-mined interactions from Literome
Sloand et al., Blood 2000
:
We studied the
effect of
G-CSF on
interferon (IFN)-gamma and IL-4 expression in CD4 ( + ) lymphocytes
Nawa et al., Bone Marrow Transplant 2000
(Graft vs Host Disease) :
G-CSF reduces
IFN-gamma and IL-4 production by T cells after allogeneic stimulation by indirectly modulating monocyte function
von Aulock et al., J Pharmacol Exp Ther 2004
:
However, flurbiprofen did not affect
G-CSF mediated decrease in tumor necrosis factor-alpha or
interferon-gamma release
Shaklee et al., Cytokine 2004
:
G-CSF decrease of IL-18 production may be a major mechanism explaining the
effects of
G-CSF on the production of
IFN-gamma
Ohta et al., Am J Reprod Immunol 2004
(Ovarian Neoplasms) :
In this study, we analyzed the
effects of
G-CSF on
interferon (IFN)-gamma production and autologous tumor killing (ATK) activities of peripheral blood mononuclear cells ( PBMCs )
Galy et al., J Immunol 1991
:
Only
IFN-gamma , and not IL-4,
suppressed the IL-1 induced
G-CSF and IL-8 production, as shown at both the protein and mRNA levels
Liu et al., Ann Hematol 2007
(Anemia, Aplastic) :
Interferon-gamma attenuates the survival activity of
G-CSF through PI3K/Akt signaling pathway in mouse multipotent progenitor cells
Shieh et al., J Immunol 1991
:
125I-G-CSF bound to PEM has a half-life of 30 min at 37 degrees C. Preincubation of PEM with murine rTNF, murine recombinant granulocyte-macrophage CSF, CSF-1, or G-CSF for 30 min at 37 degrees C resulted in partial reduction of 125I-G-CSF binding capacity, whereas IL-1 or
IFN-gamma did not
inhibit G-CSF binding
de Wit et al., Exp Hematol 1993
:
Interferon-gamma enhances the LPS induced
G-CSF gene expression in human adherent monocytes, which is regulated at transcriptional and posttranscriptional levels ... The augmented
G-CSF mRNA expression in
response to
IFN-gamma plus LPS was the result of a slight increase in the G-CSF transcription rate ( 2.2-fold ) and a more than 6-fold increase in the G-CSF mRNA half-life ( 20 minutes vs. > 120 minutes ) ... In addition, it was shown that the
effects of
IFN-gamma on LPS induced
G-CSF protein secretion could be mimicked by the calcium ionophore A23187, suggesting that the Ca ( 2+ ) -dependent pathway might be triggered after binding of the ligand to the receptor ... Finally, it was observed that the potentiating
effects of
IFN-gamma on LPS induced
G-CSF secretion could be blocked by interleukin-4 (IL-4)
Bovolenta et al., FEBS Lett 1996
:
Granulocyte colony stimulating factor induces the binding of STAT1 and STAT3 to the
IFNgamma response region within the promoter of the Fc(gamma)RI/CD64 gene in human neutrophils