Gene interactions and pathways from curated databases and text-mining

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CRK — IKBKB

Text-mined interactions from Literome

Chen et al., Eur J Pharmacol 2006 : A p38 MAPK inhibitor, SB 203580, inhibited LPS stimulated COX-2 expression and IKK-beta activation suggesting that LPS may activate the NF-kappaB signaling pathway via upstream p38 MAPK activation
Noman et al., Innate Immun 2009 : Thalidomide prevented the activation of nuclear factor (NF)-KB by down regulating phosphorylation of inhibitory KB factor ( IKB ), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide inhibited LPS induced phosphorylation of AKT, p38 and stress activated protein kinase ( SAPK ) /JNK ... Thalidomide prevented the activation of nuclear factor (NF)-KB by down regulating phosphorylation of inhibitory KB factor ( IKB ), and IKB kinase (IKK)-alpha and IKK-beta Moreover, thalidomide inhibited LPS induced phosphorylation of AKT, p38 and stress activated protein kinase ( SAPK ) /JNK