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DKK2 — WNT1

Text-mined interactions from Literome

Brott et al., Mol Cell Biol 2002 : Although Wnt8 signaling is inhibited by both Dkk1 and Dkk2 in Xenopus embryos, the same pathway is activated upon interaction of Dkk2 with the Wnt coreceptor LRP6
Li et al., Nat Genet 2005 : Because expression of another Wnt antagonist, FRP3, differs from Dkk2 expression in rescuing Dkk2 deficiency and regulating osteoblast differentiation, the effects of Dkk2 on terminal osteoblast differentiation may not be entirely mediated by its Wnt signaling antagonistic activity
Bao et al., Science signaling 2012 : The structural basis of DKK mediated inhibition of Wnt/LRP signaling
Li et al., Proc Natl Acad Sci U S A 2012 (Diabetes Mellitus, Type 2) : DKK2 deficiency did not cause in increase in insulin production but resulted in increased Wnt activity and GLP1 production in the intestines
Chang et al., PloS one 2012 : DKK , an inhibitor of Wnt signaling, abolished Wnt3a induced effect but did not interfere GSK-3ß/14-3-3s binding
Zhu et al., Carcinogenesis 2012 (Neoplasm Invasiveness...) : Furthermore, epigenetic modification of the Dickkopf ( DKK ) family ( DKK1-DKK4 ) has been shown to be important in Wnt signaling regulation
Tamura et al., Clinical calcium 2013 (Wnt Signaling Pathway) : Recently, numerous studies suggest that PTH enhances bone formation through the suppression of sclerostin, DKK1 and sFRP1, inhibitors of Wnt-ß-catenin signal