◀ Back to GRB2
GDNF — GRB2
Pathways - manually collected, often from reviews:
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NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF)
(modification, collaborate)
Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2)
(modification, collaborate)
Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
SOS1 (SOS1)
→
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2)
(modification, collaborate)
Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF)
→
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2)
(modification, collaborate)
Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
IRS2 (IRS2)
→
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
(modification, activates)
Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
→
IRS2 (IRS2)
(modification, activates)
Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/Shank3/Grb2 complex (RET-SHANK3-GRB2-GFRA1-GDNF)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, activates)
Schuetz et al., J Cell Biol 2004
Evidence: mutant phenotype, assay
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET9/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF)
(modification, collaborate)
Kurokawa et al., Oncogene 2001
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF)
(modification, collaborate)
Kurokawa et al., Oncogene 2001
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
SHP2 (PTPN11)
→
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF)
(modification, collaborate)
Kurokawa et al., Oncogene 2001
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF)
→
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF)
(modification, collaborate)
Kurokawa et al., Oncogene 2001
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF)
→
GRB2 (GRB2)
(modification, collaborate)
Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF)
→
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2)
(modification, collaborate)
Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2)
(modification, collaborate)
Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
SOS1 (SOS1)
→
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2)
(modification, collaborate)
Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET9/GFRalpha1/GDNF/Shank3 complex (RET-SHANK3-GFRA1-GDNF)
(modification, collaborate)
Schuetz et al., J Cell Biol 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET9/GFRalpha1/GDNF/Shank3/Grb2 complex (RET-SHANK3-GRB2-GFRA1-GDNF)
(modification, collaborate)
Schuetz et al., J Cell Biol 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/Shank3 complex (RET-SHANK3-GFRA1-GDNF)
→
RET9/GFRalpha1/GDNF/Shank3/Grb2 complex (RET-SHANK3-GRB2-GFRA1-GDNF)
(modification, collaborate)
Schuetz et al., J Cell Biol 2004
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF)
→
GRB2 (GRB2)
(modification, collaborate)
Hayashi et al., Oncogene 2000
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF)
→
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
(modification, collaborate)
Hayashi et al., Oncogene 2000
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
Gab1 (GAB1)
→
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
(modification, collaborate)
Hayashi et al., Oncogene 2000
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
(modification, collaborate)
Hayashi et al., Oncogene 2000
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
Gab1 (GAB1)
→
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
(modification, collaborate)
Hayashi et al., Oncogene 2000
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
(modification, collaborate)
Hayashi et al., Oncogene 2000
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF)
(modification, collaborate)
Hayashi et al., Oncogene 2000
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1)
→
RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF)
(modification, collaborate)
Hayashi et al., Oncogene 2000
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET51/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF)
(modification, collaborate)
Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
GRB2 (GRB2)
→
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF)
(modification, collaborate)
Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
RET51/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF)
→
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF)
(modification, collaborate)
Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
Evidence: assay, physical interaction, other species
-
NCI Pathway Database Signaling events regulated by Ret tyrosine kinase:
SHP2 (PTPN11)
→
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF)
(modification, collaborate)
Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
Evidence: assay, physical interaction, other species
Text-mined interactions from Literome
Murakami et al., Biochem Biophys Res Commun 1999
(Multiple Endocrine Neoplasia Type 2a...) :
Tyrosine phosphorylation of
Grb2 associated binder-1 (Gab1) and activation of phosphatidylinositol 3-kinase ( PI 3-kinase ) were
induced at higher levels by
GDNF stimulation or the MEN 2B mutation than by the MEN 2A mutation
He et al., Stem Cells 2008
:
All 3 isoforms of Shc were phosphorylated upon GDNF stimulation, and
GDNF induced the binding of the phosphorylated Ret to Shc and
Grb2 as indicated by immunoprecipitation and Western blotting