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PDGFB — SPARC

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PDGFB — SPARC (direct interaction, pull down) Raines et al., Proc Natl Acad Sci U S A 1992

Text-mined interactions from Literome

Raines et al., Proc Natl Acad Sci U S A 1992 (Arteriosclerosis) : SPARC inhibited the binding of PDGF-BB and PDGF-AB , but not PDGF-AA, to human dermal fibroblasts in a dose dependent manner
Atorrasagasti et al., Am J Physiol Gastrointest Liver Physiol 2011 (Liver Cirrhosis) : Our data together suggest that the upregulation of SPARC previously reported for aHSCs partially mediates profibrogenic activities of TGF-ß ( 1 ) and PDGF-BB and identify SPARC as a potential therapeutic target for liver fibrosis