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GRAP2 — MMP13

Text-mined interactions from Literome

Liacini et al., Exp Cell Res 2003 : These results suggest that induction of the MMP-13 gene by TNF-alpha is mediated by ERK, p38 , and JNK MAP kinases as well as AP-1 and NF-kappaB transcription factors
Wada et al., Immunol Lett 2005 (Sarcoma, Synovial) : A novel p38 MAP kinase inhibitor, R-130823, inhibited the release of IL-6, IL-8 and MMP-13 in a concentration dependent manner, but not that of IL-1beta or MMP-2
Cheung et al., Cancer Res 2006 (Neoplasm Invasiveness...) : In addition, we showed that the c-Jun NH ( 2 ) -terminal kinase, but not extracellular signal regulated kinase 1/2 or p38 mitogen activated protein kinase, signaling pathway was critical for GnRH mediated up-regulation of MMP , cell invasion, and motility
Junttila et al., Oncogene 2007 (Carcinoma, Squamous Cell...) : Inhibition of endogenous p38alpha or p38delta activity by adenoviral delivery of corresponding dominant negative p38 isoforms potently reduced MMP-13 and MMP-1 expressions, and suppressed the invasion of HNSCC cells through collagen
Sanka et al., Invest Ophthalmol Vis Sci 2007 : Primary human TM ( HTM ) cells treated with different actin cytoskeleton interfering agents, including cytochalasin D, latrunculin A, ethacrynic acid ( ECA ), a Rho kinase inhibitor ( Y-27632 ), and H-7 ( serine/threonine kinase inhibitor ), were examined for changes in actin cytoskeletal organization by phalloidin staining, MMP-2 activation by gelatin zymography, expression of MT1-MMP by quantitative real-time PCR analysis, levels of tissue inhibitor of metalloproteinases ( TIMP-1 and TIMP-2 ), and activation of p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular signal regulated protein kinase ( ERK ) by immunoblotting
Long et al., Osteoarthritis Cartilage 2010 (Inflammation...) : Inhibition of both p38alpha and p38gamma with BIRB796 resulted in less inhibition of MMP-13 production in response to IL-1beta or FN-f than did inhibition of only p38alpha with SB203580