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JUN — NFATC2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: O/- complex () → Complex of FOS-JUN-NFATC2 (increases, FOS/JUN/NFATC2 Activity)
  Evidence: the NFATs act synergistically with AP1 (Fos/Jun) proteins on composite DNA elements which contain adjacent NFAT and AP-1 binding sites, where they form highly stable ternary complexes to regulate the expression of diverse inducible genes
• OpenBEL Selventa BEL large corpus: NFATC2 → Complex of FOS-JUN-NFATC2 (increases, FOS/JUN/NFATC2 Activity)
  Evidence: the NFATs act synergistically with AP1 (Fos/Jun) proteins on composite DNA elements which contain adjacent NFAT and AP-1 binding sites, where they form highly stable ternary complexes to regulate the expression of diverse inducible genes
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → PKC theta (PRKCQ) (transcription, activates) Villalba et al., J Immunol 1999, Macián et al., EMBO J 2000
  Evidence: mutant phenotype, reporter gene
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → IL2 (IL2) (transcription, inhibits) Iacobelli et al., J Immunol 2000
  Evidence: reporter gene
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Iacobelli et al., J Immunol 2000
  Evidence: reporter gene
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: NFAT1/JUN/FOS complex (FOS-JUN-NFATC2) → FASLG (FASLG) (transcription, activates) Macián et al., EMBO J 2000, Hodge et al., Immunity 1996*, Latinis et al., J Biol Chem 1997*
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Yang et al., J Biol Chem 2000
  Evidence: reporter gene
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: Oct-1 (POU2F1) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, activates)
  Duncliffe et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IL-3 (IL3) (transcription, activates) Duncliffe et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN) (modification, collaborate)
  Yang et al., J Biol Chem 2000, Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: GRAIL (RNF128) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Anandasabapathy et al., Immunity 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN (JUN) (modification, collaborate) Yang et al., J Biol Chem 2000, Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IFN-gamma (IFNG) (transcription, activates) Curtsinger et al., J Exp Med 2003, Curtsinger et al., J Immunol 2005, Teixeira et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → STAT4 (dimer) complex (STAT4) (transcription, activates)
  Curtsinger et al., J Exp Med 2003, Curtsinger et al., J Immunol 2005, Teixeira et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → GM-CSF (CSF2) (transcription, activates) Cockerill et al., Mol Cell Biol 1995, Tokumitsu et al., Biochem Biophys Res Commun 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN) → NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) (modification, collaborate)
  Yang et al., J Biol Chem 2000, Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) → JUN (JUN) (modification, collaborate) Yang et al., J Biol Chem 2000, Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1/FOXP3 complex (NFATC2-FOXP3) → JUN/FOS/NFAT1 complex (FOS-JUN-NFATC2) (transcription, inhibits)
  Wu et al., Cell 2006
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: T-bet (TBX21) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, activates)
  Campbell et al., Transplantation 1996
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4-active complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Jain et al., Nature 1993, Chen et al., Nature 1998
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS complex (FOS-JUN) (modification, collaborate) Jain et al., Nature 1993, Chen et al., Nature 1998
  Evidence: physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN/FOS/NFAT1-c-4-active complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN/FOS complex (FOS-JUN) (modification, collaborate) Jain et al., Nature 1993, Chen et al., Nature 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → IL2 (IL2) (transcription, inhibits) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: EGR3 (EGR3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Safford et al., Nat Immunol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: FOS (FOS) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN (JUN) (modification, collaborate) Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN (JUN) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → GM-CSF (CSF2) (transcription, activates) Cockerill et al., Mol Cell Biol 1995, Tokumitsu et al., Biochem Biophys Res Commun 1993
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) (transcription, activates)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: GRAIL (RNF128) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Anandasabapathy et al., Immunity 2003
  Evidence: mutant phenotype, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: Oct-1 (POU2F1) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, activates)
  Duncliffe et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IL-3 (IL3) (transcription, activates) Duncliffe et al., Immunity 1997
  Evidence: physical interaction
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: Interferon receptor/Type I IFN complex (IFNAR1-IFNAR2-IFNA5_IFNA10_IFNA16_IFNA6_IFNA4_IFNA21_IFNA14_IFNA7_IFNA2_IFNA13_IFNA17_IFNA8) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, activates)
  Curtsinger et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IFN-gamma (IFNG) (transcription, activates) Curtsinger et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: EGR2 (EGR2) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Safford et al., Nat Immunol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → IL2 (IL2) (transcription, activates) Safford et al., Nat Immunol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/PPARG complex (NFATC1_NFATC2_NFATC3-PPARG) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Chung et al., Mol Pharmacol 2003
  Evidence: reporter gene
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN (JUN) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → JUN (JUN) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: FOS (FOS) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → ICER1 (CREM) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN (JUN) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1/FOXP3 complex (NFATC2-FOXP3) → JUN/FOS/NFAT1 complex (FOS-JUN-NFATC2) (modification, collaborate)
  Wu et al., Cell 2006
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1/FOXP3 complex (NFATC2-FOXP3) → JUN (JUN) (modification, collaborate) Wu et al., Cell 2006
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1 (NFATC2) → JUN/FOS/NFAT1 complex (FOS-JUN-NFATC2) (modification, collaborate)
  Wu et al., Cell 2006
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1 (NFATC2) → JUN (JUN) (modification, collaborate) Wu et al., Cell 2006
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: FOS (FOS) → JUN/FOS/NFAT1 complex (FOS-JUN-NFATC2) (modification, collaborate)
  Wu et al., Cell 2006
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: FOXP3 (FOXP3) → JUN/FOS/NFAT1 complex (FOS-JUN-NFATC2) (modification, collaborate)
  Wu et al., Cell 2006
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1 complex (FOS-JUN-NFATC2) → JUN (JUN) (modification, collaborate) Wu et al., Cell 2006
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JNK2 (MAPK9) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (transcription, inhibits)
  Conze et al., J Exp Med 2002, Kim et al., EMBO J 2002, Jain et al., J Immunol 1992
  Evidence: mutant phenotype, reporter gene, physical interaction, other species
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN (JUN) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → FOS (FOS) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → p21SNFT (BATF3) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → JUN (JUN) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: FOS (FOS) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → p21SNFT (BATF3) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcineurin-regulated NFAT-dependent transcription in lymphocytes: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN (JUN) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., J Immunol 1992, Jain et al., Nature 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN (JUN) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) → JUN (JUN) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: FOS (FOS) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → ICER1 (CREM) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN (JUN) (modification, collaborate) Bodor et al., J Biol Chem 1998
  Evidence: physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: NFAT1-c-4-active (NFATC1/NFATC2/NFATC3) → JUN (JUN) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → FOS (FOS) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → p21SNFT (BATF3) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/NFAT1-c-4/p21SNFT complex (JUN-NFATC1_NFATC2_NFATC3-BATF3) → JUN (JUN) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: FOS (FOS) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) (modification, collaborate)
  Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → p21SNFT (BATF3) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → JUN (JUN) (modification, collaborate) Iacobelli et al., J Immunol 2000, Jain et al., Nature 1993
  Evidence: assay, physical interaction
• NCI Pathway Database Calcium signaling in the CD4+ TCR pathway: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → NFAT1-c-4/ICER1 complex (NFATC1_NFATC2_NFATC3-CREM) (transcription, activates)
  Jain et al., J Immunol 1992, Jain et al., Nature 1993, Bodor et al., J Biol Chem 1998
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: JUN — NFATC2 Jin et al., Nat Struct Biol 2003*, Chen et al., Nature 1998
• IRef Bind Interaction: JUN — NFATC2 Chen et al., Nature 1998
• IRef Bind Interaction: JUN — NFATC2 Chen et al., Nature 1998
• IRef Bind_translation Interaction: JUN — NFATC2 (x-ray crystallography) Chen et al., Nature 1998
• IRef Biogrid Interaction: NFATC2 — JUN (direct interaction, pull down) Nguyen et al., Mol Immunol 2010*
• MIPS CORUM NFAT-JUN-FOS DNA-protein complex: NFAT-JUN-FOS DNA-protein complex complex (FOS-JUN-NFATC2) Chen et al., Nature 1998
• IRef Dip Interaction: Complex of FOS-NFATC2-JUN-FOS-NFATC2-JUN (physical association, fluorescent resonance energy transfer) Shyu et al., Proc Natl Acad Sci U S A 2008*
• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999
• IRef Hprd Interaction: Complex of FOS-JUN-NFATC2-JUN-FOS-NFATC2-NFATC2-FOS-JUN (in vivo) Giffin et al., Nat Struct Biol 2003*, Jain et al., Nature 1993, Chen et al., Nature 1998
• IRef Innatedb Interaction: NFATC2 — JUN (unknown, -) Nguyen et al., Mol Immunol 2010*
• IRef Ophid Interaction: NFATC2 — JUN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Ortega-Pérez et al., J Biol Chem 2005 : c-Jun N-terminal kinase (JNK) positively regulates NFATc2 transactivation through phosphorylation within the N-terminal regulatory domain
Bemer et al., Eur J Immunol 1996 : Furthermore, we present the first direct evidence that the nuclear factor AP-1 is present in the nucleus of the T cells primed for 48 h in presence of CSA and that withdrawal of the immunosuppressor leads to the translocation of NFATp from the cytoplasm to the nucleus