Huwait et al., Cell Signal 2011
:
The expression of ApoE and ABCA1 induced by synthetic or natural LXR ligands [ TO901317, GW3965, and 22- ( R ) -hydroxycholesterol ( 22- ( R ) -HC ), respectively ] was attenuated by inhibitors of c-Jun N-terminal kinase (JNK) ( curcumin and SP600125 ) and phosphoinositide 3-kinase (PI3K) ( LY294002 )
Li et al., Int J Mol Med 2013
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In conclusion, the c-Jun-AP-1 dependent downregulation of CD36 and the HO-1 dependent upregulation of ABCG1, SR-BI and ABCA1 may mediate the beneficial effects of kaempferol on foam cell formation