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CREB5 — GCG
Text-mined interactions from Literome
Dalle et al., J Biol Chem 2004
:
Remarkably,
glucagon promotes the nuclear translocation of ERK1/2 and
induces the phosphorylation of cAMP-response element binding protein (
CREB )
Chen et al., Diabetes 2012
(Insulin Resistance) :
Glucagon action was examined using glucagon tolerance tests and
glucagon stimulated HGP,
cAMP-responsive element binding ( CREB ) phosphorylation, and expression of gluconeogenic genes in the liver and primary hepatocytes ... In addition, TRAF2 overexpression significantly increased the ability of
glucagon or a cAMP analog to
stimulate CREB phosphorylation, gluconeogenic gene expression, and HGP in primary hepatocytes
Erion et al., J Biol Chem 2013
(Diabetes Mellitus, Experimental) :
cAMP-responsive element binding protein ( CREB ) -regulated transcription coactivator 2 ( CRTC2 ) regulates transcription of gluconeogenic genes by specifying targets for the transcription factor
CREB in
response to
glucagon