Gene interactions and pathways from curated databases and text-mining

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BMP2 — IL1A

Text-mined interactions from Literome

Fukui et al., J Bone Joint Surg Am 2003 (Osteoarthritis) : In cartilage explant cultures, IL-1beta and TNF-alpha increased BMP-2 levels both intracellularly and extracellularly
Shi et al., Inflamm Res 2004 (Chondrosarcoma...) : IL-1 , but not TNF-alpha, can induce IL-6, bone morphogenic protein 2 (BMP-2) , and cyclooxygenase ( COX-2 ) expression in SW1353 cells
Aida et al., Life Sci 2004 : The expression of BMP-2 was increased at days 3, 7, and 14 of culture with IL-1alpha , while the expression of type II receptor for BMP-2 was significantly decreased in the samples
Mumme et al., European cells & materials 2012 : In osteogenically cultured BM-MSC, IL-1ß enhanced calcium deposition ( 62.2-fold ) and BMP-2 mRNA expression by differential activation of NF-?B and ERK signalling
Nakase et al., Bone 1997 : The modulatory effects of interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha on bone morphogenetic protein (BMP)-2- and -4-induced alkaline phosphatase (ALP) activity were examined in cultures of mouse MC3T3-E1 osteoblastic cells